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Diagnostic approach to limbal stem cell deficiency.
Front Ophthalmol (Lausanne)
January 2025
Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, United States.
Limbal stem cell deficiency (LSCD) is an important cause of visual and ocular morbidity. Effective diagnosis and management require a thoughtful and comprehensive evaluation of the ocular surface. This review describes the pathogenesis, diagnosis, and grading of LSCD, as well as characteristic findings via slit lamp examination, confocal microscopy, anterior segment optical coherence tomography (AS-OCT), impression cytology, and OCT angiography.
View Article and Find Full Text PDFMolecular and immune landscape of tumours in geriatric patients with non-small cell lung cancer, melanoma and renal cell carcinoma.
BMJ Oncol
January 2025
Department of Medicine, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
Objective: Cancer patients aged ≥80 years present unique characteristics affecting response to immune checkpoint inhibitors (ICIs), with unidentified molecular differences. This study aimed to explore potential biomarkers of response to ICI in patients ≥80 years.
Methods And Analysis: We analysed tumour samples (n=24 123) from patients ≥80 (versus<80) with non-small cell lung cancer (NSCLC), melanoma (MEL), and renal cell cancer (RCC).
Predictors of Antidepressant Use Among People With Multiple Sclerosis.
J Neuropsychiatry Clin Neurosci
January 2025
Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, and Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto (Freedman, Feinstein); Division of Neurology, Department of Medicine, St. Michael's Hospital, and Division of Neurology, Temerty Faculty of Medicine, University of Toronto, Toronto (Oh).
Objective: Anxiety and depression are common among individuals with multiple sclerosis (MS) but are often undertreated. Little is known about factors that influence the odds of antidepressant treatment for MS. The authors aimed to identify predictors of antidepressant use among people with MS.
View Article and Find Full Text PDFPsychiatric Symptoms Among Adolescents and Young Adults With or Without the Huntingtin Gene Expansion.
J Neuropsychiatry Clin Neurosci
January 2025
Departments of Neurology (Watson, Pfalzer, Snow, Diehl, McDonell, Claassen) and Pathology, Microbiology, and Immunology (Vnencak-Jones), Vanderbilt University Medical Center, Nashville; Department of Psychology and Human Development (Ciriegio, Snow, Compas), Vanderbilt University, Nashville; Department of Psychiatry, University of Iowa, Iowa City (Long).
Objective: Using a multi-informant approach, the authors assessed the psychiatric symptoms of adolescents and young adults with or without the huntingtin gene expansion and examined the association of psychiatric symptoms with cumulative disease exposure, a measure taking into account age and genetic data.
Methods: The sample included 110 participants with (N=71) or without (N=39) the gene expansion, along with 85 family members who provided collateral reports. Saliva samples were used for genetic testing.
Tolerability and effectiveness of face-masks in reducing cough aerosols for children with cystic fibrosis.
J Cyst Fibros
January 2025
The Prince Charles Hospital, Brisbane, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. Electronic address:
Background: People with cystic fibrosis (CF) are recommended to wear face-masks when in healthcare settings. We previously demonstrated that face-masks significantly reduce the release of Pseudomonas aeruginosa (P. aeruginosa) aerosols during coughing in adults with CF.
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