Germline Variants of Uncertain Significance in Gynecologic Oncology Patients.

Clin Obstet Gynecol

Department of Internal Medicine, Division of Human Genetics, The Ohio State University Comprehensive Cancer Center, College of Medicine, Columbus, Ohio.

Published: December 2024

Germline and somatic genetic/genomic testing are commonly ordered for gynecologic oncology patients. Genetic tests can inform disease etiology, prognosis, treatment decisions, and risk to the patient's relatives. Variants of uncertain significance (VUSs) are frequently encountered and have a more nuanced interpretation than straightforward pathogenic or benign variant classifications. Clinical care providers should be familiar with why and how VUSs are reported, their clinical significance, variant reclassification practices, and patient perceptions of VUSs.

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Source
http://dx.doi.org/10.1097/GRF.0000000000000898DOI Listing

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