ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.

Jeffrey J Rodvold Matthew Grimmer Karen Ruiz Scot A Marsters Ioanna Oikonomidi Eileen Tan-Aristy Victoria C Pham Tamal Sarkar Jonathan M Harnoss Whitney Shatz-Binder Zora D Modrusan Thomas D Wu Jennie R Lill Elisia Villemure Joachim Rudolph Felipe de Sousa E Melo Avi Ashkenazi

Cancer Res Commun

Department of Research Oncology, Genentech, Inc., South San Francisco, California.

Published: October 2024

* Wnt signaling is often altered in colorectal cancer, and ATF6 serves as a novel facilitator in this process.
* Targeting ATF6 could present a new therapeutic strategy for treating colorectal cancer.

ATF6 intervention reduces colorectal cancer cell and organoid viability by interrupting dysregulated Wnt signaling, identifying a novel facilitator and potential therapeutic target in colorectal cancer.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492184	PMC
http://dx.doi.org/10.1158/2767-9764.CRC-24-0268	DOI Listing

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