AI Article Synopsis
- - The study focuses on antibiotic resistance patterns of Gram-negative bacteria, particularly in an Intensive Care Unit (ICU) setting, highlighting the critical need to monitor and address this issue due to high rates of bacterial infections in critically ill patients.
- - A total of 500 samples were analyzed over 18 months, with 451 samples showing growth; Escherichia coli was identified as the most prevalent organism, exhibiting significant resistance to standard antibiotics, especially Ciprofloxacin.
- - The findings suggest that Escherichia coli's resistance to commonly used antibiotics limits treatment options, emphasizing the necessity for ongoing surveillance and strict infection control measures in healthcare facilities, especially in ICU areas.
Article Abstract
Background Intensive care unit (ICU) is the especial department of the hospital where critically ill patients are treated with the unique type of technologies to revert back to functional by body's own mechanism. Therefore, there are lots of external intervention with chance of getting bacterial infections. Antibiotics are medicines used to prevent and treat such bacterial infections. However, due to selective broad spectrum antibiotic pressure there is great chances to develop antimicrobial resistance at any time during hospital stay in intensive care unit. Objective To find out the antibiotic resistance pattern among Gram negative bacteria in Intensive Care Unit. Method A Descriptive cross-sectional study was conducted in Department of Microbiology of Tertiary care center for 18 months On the basis of previous sample load census method was used to include 500 sample from intensive care unit during study period. Among them only Gram negative bacteria were included in the study. All the samples were processed following standard methodology. Result Out of 500 samples, growth was observed in 451 (90.2%) samples. Among all the isolates Escherichia coli (29.6%) was predominant organism. It had shown high resistance towards Ciprofloxacin (93.5%) even in urine sample Ciprofloxacin (86.9%). Conclusion Our study showed Escherichia coli as a major organism in intensive care unit. This was resistant to commonly used oral antibiotic leaving restricted option for use of higher antibiotics. Therefore, continuous surveillance of such bacterial pathogen is warranted with implementation of effective Infection Prevention and Control measures in Health Care setting with emphasis to critical care units.
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