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| http://dx.doi.org/10.1017/S0033291724002149 | DOI Listing |
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Associations between structural brain changes and blood neurofilament light chain protein in treatment-resistant schizophrenia.
Aust N Z J Psychiatry
January 2025
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia.
Objective: Around 30% of people with schizophrenia are refractory to antipsychotic treatment (treatment-resistant schizophrenia). Abnormal structural neuroimaging findings, in particular volume and thickness reductions, are often described in schizophrenia. Novel biomarkers of active brain pathology such as neurofilament light chain protein are now expected to improve current understanding of psychiatric disorders, including schizophrenia.
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National Council of Scientific and Technical Research (CONICET), Buenos Aires, Argentina.
Increased structural covariance of cortical measures in individuals with an at-risk mental state.
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January 2025
Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama city, Toyama 930-0194, Japan; Research Center for Idling Brain Science, University of Toyama, 2630 Sugitani, Toyama city, Toyama 930-0194, Japan.
An anomalous pattern of structural covariance has been reported in schizophrenia, which has been suggested to represent connectome changes during brain maturation and neuroprogressive processes. It remains unclear whether similar differences exist in a clinical high-risk state for psychosis, and if they are associated with a prodromal phenotype and/or later psychosis onset. This multicenter magnetic resonance imaging study cross-sectionally examined structural covariance in a large at-risk mental state (ARMS) sample with different outcomes.
View Article and Find Full Text PDFClaudin-5 and occludin levels in patients with psychiatric disorders - A systematic review.
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Department of Psychiatry, University of Toronto, Toronto, Canada; Centre for Addiction and Mental Health, Toronto, Canada; Poul Hansen Family Centre for Depression, Centre of Mental Health, University Health Network, Toronto, Canada. Electronic address:
Background: Recent research has underscored the critical role of blood-brain barrier (BBB) integrity in psychiatric disorders, highlighting disruptions in tight junction (TJ) proteins, specifically claudin-5 and occludin. These proteins are pivotal in maintaining the BBB's selective permeability, which is essential forbrain homeostasis. Altered levels of the TJ proteins have been observed in various psychiatric conditions, suggesting potential as biomarkers for the pathophysiology of these disorders.
View Article and Find Full Text PDFSymptom management for people with advanced dementia who are receiving end of life care.
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University of Glasgow, School of Medicine, Dentistry and Nursing, Glasgow, UK.
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