AI Article Synopsis
- The study investigated how hyperthermic therapy (HT) affects mice on different diets (normal vs. high-fat) over several weeks with multiple HT sessions.
- Mice placed in a controlled environment showed symptoms like weight gain, fat accumulation, and glucose intolerance due to the high-fat diet.
- HT treatment improved muscle health, reduced weight gain, normalized glucose levels, and positively impacted inflammation and insulin resistance markers in adipose tissue.
Article Abstract
Aim: This study examined the effects of hyperthermic therapy (HT) on mice fed normal chow or a high-fat diet (HFD) for 18 or 22 weeks, undergoing four or eight weekly HT sessions.
Methods: Mice were housed within their thermoneutral zone (TNZ) to simulate a physiological response. HFD-induced obesity-related changes, including weight gain, visceral fat accumulation, muscle loss (indicative of obesity sarcopenia), glucose intolerance, and hepatic triglyceride buildup.
Main Results: HT upregulated HSP70 expression in muscles, mitigated weight gain, normalised QUICK index, and reduced plasma HSP70 concentrations. It also lowered the H-index of HSP70 balance, indicating improved immunoinflammatory status, and decreased activated caspase-1 and proliferative senescence in adipose tissue, both linked to insulin resistance.
Conclusion: The findings suggest that even animals on a "control" diet but with insufficient physical activity and within their TNZ may experience impaired glycaemic homeostasis.
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Source |
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| http://dx.doi.org/10.1080/13813455.2024.2406904 | DOI Listing |
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