Ischemic stroke is the fourth leading cause of adult disability in the US, and it is a huge social burden all over the world. However, the efficient treatment of ischemic stroke is not available. An apparent reason for failing to find or develop an intervention for ischemic stroke is contributed to the tight blood-brain barrier (BBB). The unique characteristics of exosomes that can traverse BBB have been highlighted among researchers investigating interventions for ischemic stroke conditions. Additionally, intermittent hypoxic training has been considered a potential intervention in the treatment or rehabilitation process of ischemic stroke patients. In this mini-review, we are going to review the possibility of applying exosomes produced by a subject who does intermittent hypoxic conditioning in a treatment program for ischemic stroke.
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http://dx.doi.org/10.3389/fnint.2024.1475234 | DOI Listing |
Acta Neurol Belg
December 2024
Department of Neurology, School of Medicine, The 2nd Affiliated Hospital of Zhejiang University, #88 Jiefang Road, Hangzhou, China.
Ischemic stroke, accounting for approximately 80% of all stroke cases, remains a leading cause of death and disability worldwide. Effective management of ischemic stroke is heavily influenced by its etiology, which can range from large-artery atherosclerosis and cardiac embolism to cerebral small-vessel occlusions and cryptogenic strokes. Cardioembolic stroke, which makes up about 30% of ischemic strokes, often leads to more severe symptoms and worse outcomes, necessitating anticoagulation therapy for prevention.
View Article and Find Full Text PDFBioprocess Biosyst Eng
December 2024
Department of Biological Engineering, Inha University, 100 Inha-Ro, Nam-Gu, Incheon, 22212, Republic of Korea.
Experimental models for exploring abnormal brain blood vessels, including ischemic stroke, are crucial in neuroscience; recently, significant attention has been paid to artificial tissues through tissue engineering. Nanofibers, although commonly used as tissue engineering scaffolds, undergo structural deformations easily, making it challenging to create uniform tissue, especially for the smallest-diameter ones such as perforating arteries. This study focused on the development of a platform capable of reconstructing structurally and functionally replicated perforating arteries.
View Article and Find Full Text PDFAnn Neurol
December 2024
Department of Neurology, Seoul National University Bundang Hospital, Seongnam-si, South Korea.
Objective: Computed tomography perfusion (CTP) imaging is crucial in quantifying cerebral blood flow (CBF) and thereby making an endovascular treatment (EVT) after large vessel occlusion. However, CTP is prone to overestimating the ischemic core. We sought to delineate the optimal regional CBF (rCBF) thresholds of pre-EVT CTP.
View Article and Find Full Text PDFFront Neurosci
December 2024
Department of Neurology, Dongyang People's Hospital, Affiliated to Wenzhou Medical University, Dongyang, China.
Background And Aim: This study aimed to develop a predictive model for early neurological deterioration (END) in branch atheromatous disease (BAD) affecting the lenticulostriate artery (LSA) territory using machine learning. Additionally, it aimed to explore the underlying mechanisms of END occurrence in this context.
Methods: We conducted a retrospective analysis of consecutive ischemic stroke patients with BAD in the LSA territory admitted to Dongyang People's Hospital from January 1, 2018, to September 30, 2023.
Cureus
November 2024
Neurosurgery, Baptist Health Neuroscience Partners Neurosurgery, Baptist Medical Center South, Montgomery, USA.
Introduction: Stroke is one of the common causes of mortality. The length of stay (LOS) for a stroke is a quality indicator and affects mortality. However, there are no large studies evaluating the LOS in an acute inpatient setting for stroke patients, mainly hematological and social parameters.
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