AI Article Synopsis
- Gait disturbances significantly impact the quality of life for Parkinson's disease patients, with current treatments only providing limited benefits.
- Deep brain stimulation (DBS) usually targets symptoms like tremors, but is not very effective for improving gait issues.
- A novel approach called adaptive DBS was tested on one patient, leading to notable improvements in walking and overall symptom management, suggesting it may help optimize stimulation for better gait outcomes.
Article Abstract
Gait disturbance is a common and severe symptom of Parkinson's disease that severely impairs quality of life. Current treatments provide only partial benefits with wide variability in outcomes. Also, deep brain stimulation of the subthalamic nucleus (STN-DBS), a mainstay treatment for bradykinetic-rigid symptoms and parkinsonian tremor, is poorly effective on gait. We applied a novel DBS paradigm, adjusting the current amplitude linearly with respect to subthalamic beta power (adaptive DBS), in one parkinsonian patient with gait impairment and chronically stimulated with conventional DBS. We studied the kinematics of gait and gait initiation (anticipatory postural adjustments) as well as subthalamic beta oscillations with both conventional and adaptive DBS. With adaptive DBS, the patient showed a consistent and long-lasting improvement in walking while retaining benefits on other disease-related symptoms. We suggest that adaptive DBS can benefit gait in Parkinson's disease possibly by avoiding overstimulation and dysfunctional entrainment of the supraspinal locomotor network.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423205 | PMC |
| http://dx.doi.org/10.3389/fbioe.2024.1428189 | DOI Listing |
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