In statistical applications, it is common to encounter parameters supported on a varying or unknown dimensional space. Examples include the fused lasso regression, the matrix recovery under an unknown low rank, etc. Despite the ease of obtaining a point estimate via optimization, it is much more challenging to quantify their uncertainty. In the Bayesian framework, a major difficulty is that if assigning the prior associated with a -dimensional measure, then there is zero posterior probability on any lower-dimensional subset with dimension . To avoid this caveat, one needs to choose another dimension-selection prior on , which often involves a highly combinatorial problem. To significantly reduce the modeling burden, we propose a new generative process for the prior: starting from a continuous random variable such as multivariate Gaussian, we transform it into a varying-dimensional space using the proximal mapping. This leads to a large class of new Bayesian models that can directly exploit the popular frequentist regularizations and their algorithms, such as the nuclear norm penalty and the alternating direction method of multipliers, while providing a principled and probabilistic uncertainty estimation. We show that this framework is well justified in the geometric measure theory, and enjoys a convenient posterior computation via the standard Hamiltonian Monte Carlo. We demonstrate its use in the analysis of the dynamic flow network data.
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http://dx.doi.org/10.1080/01621459.2023.2220170 | DOI Listing |
Comput Med Imaging Graph
January 2025
CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing 100049, China; National Key Laboratory of Kidney Diseases, Beijing 100853, China. Electronic address:
In clinical optical molecular imaging, the need for real-time high frame rates and low excitation doses to ensure patient safety inherently increases susceptibility to detection noise. Faced with the challenge of image degradation caused by severe noise, image denoising is essential for mitigating the trade-off between acquisition cost and image quality. However, prevailing deep learning methods exhibit uncontrollable and suboptimal performance with limited interpretability, primarily due to neglecting underlying physical model and frequency information.
View Article and Find Full Text PDFmBio
January 2025
Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Many bacterial toxins exert their cytotoxic effects by enzymatically inactivating one or more cytosolic targets in host cells. To reach their intracellular targets, these toxins possess functional domains or subdomains that interact with and exploit various host factors and biological processes. Despite great progress in identifying many of the key host factors involved in the uptake of toxins, significant knowledge gaps remain as to how partially characterized and newly discovered microbial toxins exploit host factors or processes to intoxicate target cells.
View Article and Find Full Text PDFActa Psychol (Amst)
January 2025
Department of Linguistics, Cognitive Science, and Semiotics, Aarhus University, Jens Chr. Skous Vej 2, 1485-638 Aarhus, Denmark; Interacting Minds Centre, Aarhus University, Jens Chr. Skous Vej 2, 1485-638 Aarhus, Denmark. Electronic address:
When two co-actors perform a joint action, they often communicatively modulate their instrumental actions so as to facilitate each other's predictions of their immediate, proximal goals. Here, we ask whether co-actors would also engage in such "sensorimotor communication" for distal goals, specifically those that result from a two-step action sequence. To address this question, we asked pairs of participants to work together to deliver an animated box to one of two delivery locations displayed on a computer screen.
View Article and Find Full Text PDFJ Orthop
July 2025
Department of Hand Surgery, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Aims And Objectives: Dynamic incursion of lumbrical muscle proximal to the distal edge of transverse carpal ligament (TCL) has been long debated for its role in causing median nerve compression in the carpal tunnel. This study aims to evaluate the pattern of lumbrical incursion into the carpal tunnel in various finger positions and determine their extent of presence and relationship with respect to the TCL and to each other in the carpal tunnel.
Materials & Methods: Dissection of 30 fresh frozen cadaveric hands was done to map the lumbrical muscles.
Med Biol Eng Comput
January 2025
Department of Pediatric Orthopedics, Xinhua Hospital Affiliated With Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Proximal femoral fractures in children are challenging in clinical treatment due to their unique anatomical and biomechanical characteristics. The distribution and characteristics of fracture lines directly affect the selection of treatment options and prognosis. Pediatric proximal femur fractures exhibit distinctive features, with the distribution and characteristics of the fracture line playing a crucial role in deciding optimal treatment.
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