Hippocampal atrophy in Alzheimer's disease (AD) is asymmetric and spatially inhomogeneous. While extensive work has been done on volume and shape analysis of atrophy of the hippocampus in AD, less attention has been given to hippocampal asymmetry specifically. Previous studies of hippocampal asymmetry are limited to global volume or shape measures, which don't localize shape asymmetry at the point level. In this paper, we propose to quantify localized shape asymmetry by optimizing point correspondences between left and right hippocampi within a subject, while simultaneously favoring a compact statistical shape model of the entire sample. To account for related variables that have an impact on AD and healthy subject differences, we build linear models with other confounding factors. Our results on the OASIS3 dataset demonstrate that compared to volumetric information, shape asymmetry reveals fine-grained, localized differences that inform us about the hippocampal regions of most significant shape asymmetry in AD patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423258 | PMC |
| http://dx.doi.org/10.1109/isbi56570.2024.10635697 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Two-Dimensional and Three-Dimensional Changes in Deformational Head Shapes During Repositioning Therapy and Cranial Remolding Treatment.
J Clin Med
December 2024
Analytical Imaging and Modeling Center, Children's Health, 1935 Medical District Drive, Dallas, TX 75235, USA.
The surge in deformational head shapes (DHSs) over the past 30 years has led to increased interest in comparing the treatment options of Repositioning Therapy (RT) and a Cranial Remolding Orthosis (CRO). This study investigates the amount and rate of 2D and 3D correction in infants with DHSs during these treatments. A total of 34 infants with DHSs were enrolled (RT group, = 18; CRO group, = 16).
View Article and Find Full Text PDFBreaking Left-Right Symmetry by the Interplay of Planar Cell Polarity, Calcium Signaling and Cilia.
Cells
December 2024
Laboratoire de Biologie du Développement, LBD, CNRS UMR7622, INSERM U1156, Sorbonne Université, F-75005 Paris, France.
The formation of the embryonic left-right axis is a fundamental process in animals, which subsequently conditions both the shape and the correct positioning of internal organs. During vertebrate early development, a transient structure, known as the left-right organizer, breaks the bilateral symmetry in a manner that is critically dependent on the activity of motile and immotile cilia or asymmetric cell migration. Extensive studies have partially elucidated the molecular pathways that initiate left-right asymmetric patterning and morphogenesis.
View Article and Find Full Text PDFAssessment of Facial Asymmetry in Slovak Patients with Positional Deformity.
Children (Basel)
November 2024
Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia.
Positional deformity (PD), also known as deformational plagiocephaly or non-synostosis, is a primary cause of abnormal head shape and asymmetry in infants. The most common type, occipital plagiocephaly, leads to flattening of one side of the back of the head or the entire head (positional brachycephaly). PD results from external forces on the growing skull, often due to childbirth and improper positioning during sleep.
View Article and Find Full Text PDFMultifractal dynamic changes of spontaneous brain activity in psychiatric disorders: Adult attention deficit-hyperactivity disorder, bipolar disorder, and schizophrenia.
J Affect Disord
January 2025
School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA. Electronic address:
It is one of the strategies to study the complexity of spontaneous fluctuation of brain neurons based on resting-state functional magnetic resonance imaging (rs-fMRI), but the multifractal characteristics of spontaneous fluctuation of brain neurons in psychiatric diseases need to be studied. Therefore, this paper will study the multifractal spontaneous brain activity changes in psychiatric disorders using the multifractal detrended fluctuation analysis algorithm based on the UCLA datasets. Specifically: (1) multifractal characteristics in adult attention deficit-hyperactivity disorder (ADHD), bipolar disorder (BP), and schizophrenia (SCHZ); (2) the source of those multifractal characteristics.
View Article and Find Full Text PDFUnlabelled: Cytoplasmic proteins must recruit to membranes to function in processes such as endocytosis and cell division. Many of these proteins recognize not only the chemical structure of the membrane lipids, but the curvature of the surface, binding more strongly to more highly curved surfaces, or 'curvature sensing'. Curvature sensing by amphipathic helices is known to vary with membrane bending rigidity, but changes to lipid composition can simultaneously alter membrane thickness, spontaneous curvature, and leaflet symmetry, thus far preventing a systematic characterization of lipid composition on such curvature sensing through either experiment or simulation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!