AI Article Synopsis
- * This study explores the clinical presentation and outcomes of patients with uTTP, highlighting similarities to immune TTP (iTTP).
- * Key features like young age, brain involvement, and severe low platelet counts, especially in those with a history of autoimmune disease or pregnancy, should raise suspicion for iTTP diagnosis.
Article Abstract
In up to 25% of patients with acquired TTP, anti-ADAMTS13 antibodies are not identified, the mechanism resulting from ADAMTS13 deficiency remains unidentified (uTTP). In this study, we provide further insights on clinical presentation and outcome of uTTP. In patients with baseline undetectable anti-ADAMTS13 antibodies, usual features of iTTP (young age, cerebral involvement, severe thrombocytopenia) with no other associated context than a history of systemic autoimmune disease or pregnancy, should prompt to consider the diagnosis of iTTP.
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| http://dx.doi.org/10.3324/haematol.2024.285391 | DOI Listing |
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