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| http://dx.doi.org/10.1055/a-2410-3776 | DOI Listing |
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From setbacks to success: lessons from the journey of RSV vaccine development.
Ther Adv Vaccines Immunother
December 2024
Centre for Human Drug Research, Leiden, The Netherlands.
Respiratory syncytial virus (RSV) causes high worldwide infant mortality, as well as a high disease burden in the elderly. Efforts in vaccine development over the past 60 years have recently delivered three approved vaccines and two monoclonal antibodies (mAbs). Looking back at the eventful history of RSV vaccine development, several factors can be identified that have hampered the developmental pathway, including the occurrence of enhanced RSV disease (ERD) in the first vaccine attempt and the difficulty in characterizing and stabilizing the pre-fusion F protein as a vaccine target.
View Article and Find Full Text PDFThe battle to save the anus: a triumph of careful colonoscopy and medical history taking.
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Nurses' values when caring for persons suffering from substance use disorder: A hermeneutical study.
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Department of Caring and Ethics, Faculty of Health Sciences, University of Stavanger, Stavanger, Norway.
Article Synopsis
- Nurses caring for individuals with substance use disorders (SUD) must address complex physical, existential, and spiritual needs, requiring a strong ethical foundation.
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Leveraging computational tools to combat malaria: assessment and development of new therapeutics.
J Cheminform
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Department of Chemical Sciences, University of Johannesburg, Johannesburg, 2028, South Africa.
As the world grapples with the relentless challenges posed by diseases like malaria, the advent of sophisticated computational tools has emerged as a beacon of hope in the quest for effective treatments. In this study we delve into the strategies behind computational tools encompassing virtual screening, molecular docking, artificial intelligence (AI), and machine learning (ML). We assess their effectiveness and contribution to the progress of malaria treatment.
View Article and Find Full Text PDFRheumatoid Arthritis Has Won the Battle but Not the War: How Many Joints Will We Save Tomorrow?
Medicina (Kaunas)
October 2023
Department of Molecular Genetics and Biotechnologies, Institute of Biochemical Technologies, Ecology and Pharmacy, V.I. Vernadsky Crimean Federal University, Simferopol 295007, Crimea.
Rheumatoid arthritis refers to joint diseases of unclear etiology whose final stages can lead to unbearable pain and complete immobility of the affected joints. As one of the most widely known diseases of the joints, it serves as a study target for a large number of research groups and pharmaceutical companies. Modern treatment with anti-inflammatory drugs, including janus kinase (JAK) inhibitors, monoclonal antibodies, and botanicals (polyphenols, glycosides, alkaloids, etc.
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