AI Article Synopsis
- * The use of protamine to reverse heparin after TAVR did not show a significant reduction in major bleeding compared to the control group, with similar rates of life-threatening bleeding and other complications.
- * While protamine seems safe post-TAVR and doesn't increase stroke risk, more research is needed to confirm its effectiveness in reducing bleeding through a larger, multicentric study.
Article Abstract
Transfemoral Trans-catheter Aortic Valve Replacement (TF-TAVR) is a safe alternative to surgical aortic valve replacement (SAVR). Protamine is used to reverse heparin and reduce post-TAVR bleeding, but concerns about risks like valve thrombosis and stroke remain. This systematic review and meta-analysis, following PRISMA guidelines, found no statistically significant difference in major bleeding complications between the protamine and control groups [(3.0 % vs. 14.4 %); RR: 0.56; P = 0.16]. No differences were noted in life-threatening bleeding, blood transfusions, 30-day mortality, or stroke. Protamine appears safe post-TAVR without increasing stroke risk, but its effectiveness in reducing bleeding needs further investigation through a multicentric randomized study.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584372 | PMC |
| http://dx.doi.org/10.1016/j.ihj.2024.09.001 | DOI Listing |
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