AI Article Synopsis
- Aberrant gene expression is key in many diseases due to disruptions in mRNA processing.
- Variations in 3' end processing can be regulated or random, affecting gene expression differently—small changes allow for flexibility, while larger changes can cause serious health issues.
- Issues can stem from mutations in single genes or broader changes that impact numerous genes, highlighting the importance of understanding these processing mechanisms.
Article Abstract
Aberrant gene expression lies at the heart of many pathologies. This review will point out how 3' end processing, the final mRNA-maturation step in the transcription cycle, is surprisingly prone to regulated as well as stochastic variations with a wide range of consequences. Whereas smaller variations contribute to the plasticity of gene expression, larger alternations to 3' end processing and coupled transcription termination can lead to pathological consequences. These can be caused by the local mutation of one gene or affect larger numbers of genes systematically, if aspects of the mechanisms of 3' end processing and transcription termination are altered.
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| http://dx.doi.org/10.1016/j.jmb.2024.168802 | DOI Listing |
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