Much effort has been spent in the identification of an environmental factor that explains the occurrence of molar incisor hypomineralisation (MIH). The best explanation, however, is accepting that MIH has a complex or multifactorial mode of inheritance. This chapter provides an analysis of how multifactorial inheritance operates in determining MIH, an explanation that accommodates the variation seen in the phenotype and the frequency of the problem around the world.
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