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Meretoja's Syndrome: Lattice Corneal Dystrophy, Gelsolin Type.
Case Rep Med
January 2017
Centro Hospitalar do Porto, Hospital de Santo António, Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Lattice corneal dystrophy gelsolin type was first described in 1969 by Jouko Meretoja, a Finnish ophthalmologist. It is caused by an autosomal dominant mutation in gelsolin gene resulting in unstable protein fragments and amyloid deposition in various organs. The age of onset is usually after the third decade of life and typical diagnostic triad includes progressive bilateral facial paralysis, loose skin, and lattice corneal dystrophy.
View Article and Find Full Text PDFCyclosporine-associated leukoencephalopathy in organ transplant recipients: experience of three clinical cases.
Transplant Proc
April 2006
Department of Nephrology, Hospital del Salvador, Santiago, Chile.
Leukoencephalopathy is a structural alteration of cerebral white matter mainly involving damage to myelin. Several reports have linked cyclosporine (CsA) with this alteration. The clinical features vary from qualitative alterations of consciousness to neurological deficits.
View Article and Find Full Text PDFTreatment of Guillain-Barré syndrome induced by cyclosporine in a lung transplant patient.
J Heart Lung Transplant
January 2006
Division of Pulmonary and Critical Care Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA.
We report the case of a 58-year-old man with severe chronic obstructive pulmonary disease who developed acute quadriparesis during the post-operative period following bilateral lung transplantation after receiving cyclosporine for immunosuppression. Electromyography with nerve conduction study and cerebrospinal fluid analysis supported a diagnosis of Guillain-Barré Syndrome, which improved upon the discontinuation of cyclosporine, replacement with tacrolimus, and initiation of plasmapheresis. We propose the discontinuation of cyclosporine and initiation of plasmapheresis as a treatment for cyclosporine-associated Guillain-Barré syndrome.
View Article and Find Full Text PDFSuccessful renal transplantation after cyclosporine-associated hemolytic-uremic syndrome following bilateral lung transplantation.
Transplantation
July 1992
Department of Medicine, University of Mississippi Medical Center, Jackson 39216.
Cyclosporine-associated seizures in bone marrow transplant recipients given busulfan and cyclophosphamide preparative therapy.
Transplantation
August 1991
Bone Marrow Transplant Division, Ohio State University, Columbus 43210.
Five of 182 recipients of allogeneic bone marrow transplants performed between 2/84 and 6/90 developed seizures while receiving cyclosporine and methylprednisolone to prevent acute graft-versus-host disease. All received a radiation-free regimen of busulfan and cyclophosphamide as preparative therapy. Two patients received HLA-mismatched allografts; and three patients received marrow from HLA-identical sibling donors.
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