We report new photoluminescent switching systems achieved through pH-induced intramolecular oxa-Michael conjugate addition reactions. Ratiometric absorbance and fluorescence emission were observed across conjugate acceptors triggered by pH, resulting in specific pseudo p values. The effect of substituents on the pseudo p's was investigated, showing increased values from electron-withdrawing to electron-donating groups. Inspired by the physiologically related p, a fluorescent probe was designed, successfully distinguishing cancer cells from normal cells through live cellular imaging.
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http://dx.doi.org/10.1021/acs.orglett.4c03197 | DOI Listing |
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