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| http://dx.doi.org/10.1164/rccm.202408-1578ED | DOI Listing |
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Positive feedback loop involving AMPK and CLYBL acetylation links metabolic rewiring and inflammatory responses.
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Metabolic rewiring underlies effective macrophages defense to respond disease microenvironment. However, the underlying mechanisms driving metabolic rewiring to enhance macrophage effector functions remain unclear. Here, we demonstrated that the metabolic reprogramming in inflammatory macrophages depended on the acetylation of CLYBL, a citramalyl-CoA lyase, at lysine 154 (K154), and blocking CLYBL-K154 acetylation restricted the release of pro-inflammatory factors.
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Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC, 29425, USA.
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Department of Anesthesiology, Cathay General Hospital, Taipei 280, Taiwan.
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