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Single-Cell Multi-Omics Profiling of Immune Cells Isolated from Atherosclerotic Plaques in Male ApoE Knockout Mice Exposed to Arsenic.
Environ Health Perspect
January 2025
Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Canada.
Background: Millions worldwide are exposed to elevated levels of arsenic that significantly increase their risk of developing atherosclerosis, a pathology primarily driven by immune cells. While the impact of arsenic on immune cell populations in atherosclerotic plaques has been broadly characterized, cellular heterogeneity is a substantial barrier to in-depth examinations of the cellular dynamics for varying immune cell populations.
Objectives: This study aimed to conduct single-cell multi-omics profiling of atherosclerotic plaques in apolipoprotein E knockout () mice to elucidate transcriptomic and epigenetic changes in immune cells induced by arsenic exposure.
A Functional Variant in Is Associated with the Risk of Radiation Pneumonitis.
Am J Respir Cell Mol Biol
January 2025
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei , China;
Radiation pneumonitis (RP) is characterized by inflammation and is associated with autophagy. However, the relationship between functional genetic variants of autophagy-related genes and radiation pneumonitis remains unknow. In this study we aimed to investigate whether genetic variants of genes involved in autophagy are associated with radiation pneumonitis.
View Article and Find Full Text PDFOn-farm evaluation of swede midge (Diptera: Cecidomyiidae) susceptibility among popular kale varieties.
J Econ Entomol
January 2025
Department of Agriculture, Landscape, and Environment, University of Vermont, Burlington, VT, USA.
The swede midge, Contarinia nasturtii Kieffer (Diptera:Cecidomyiidae), is a gall-forming insect pest that targets cruciferous plants. Since its introduction to North America in the early 2000s, the midge has expanded its range to include farming regions in Quebec and the Northeastern USA. In this study, we evaluated the susceptibility of 4 popular kale varieties-Green Curly-(Vates), Red Russian, Red Curly (RedBor), and Lacinato/Tuscan-to swede midge infestation in on-farm trials conducted over consecutive years.
View Article and Find Full Text PDFConstruction of an lncRNA-mediated ceRNA network to investigate the inflammatory regulatory mechanisms of ischemic stroke.
PLoS One
January 2025
Department of Biochemistry, College of Medicine, Shihezi University, Shihezi, Xinjiang, China.
Long non-coding RNAs (lncRNAs) are among the most abundant types of non-coding RNAs in the genome and exhibit particularly high expression levels in the brain, where they play crucial roles in various neurophysiological and neuropathological processes. Although ischemic stroke is a complex multifactorial disease, the involvement of brain-derived lncRNAs in its intricate regulatory networks remains inadequately understood. In this study, we established a cerebral ischemia-reperfusion injury model using middle cerebral artery occlusion (MCAO) in male Sprague-Dawley rats.
View Article and Find Full Text PDFModes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists.
PLoS Pathog
January 2025
School of BioSciences, The University of Melbourne, Parkville, Victoria, Australia.
Pathogenic protists are responsible for many diseases that significantly impact human and animal health across the globe. Almost all protists possess mitochondria or mitochondrion-related organelles, and many contain plastids. These endosymbiotic organelles are crucial to survival and provide well-validated and widely utilised drug targets in parasitic protists such as Plasmodium and Toxoplasma.
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