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Effects of antidepressant type on allostatic load of male and female psychiatric outpatients.
J Psychiatr Res
November 2024
Mood and Anxiety Clinic Disorders, Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada.
Sex differences and antidepressant use are not systematically accounted for in studies measuring physiological dysregulations associated with chronic stress and allostatic load (AL) in neuropsychiatry. Critically, assessing commonly prescribed antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs) and selective serotonin and norepinephrine reuptake inhibitors (SNRIs) could help monitor potential iatrogenic effects on AL and health that are associated with prolonged antidepressant use. The objective of this exploratory analysis was to investigate how male and female psychiatric outpatients using either SSRIs or SNRIs differ in their AL indices.
View Article and Find Full Text PDFCombined mindfulness-based stress reduction and physical activity improved psychological factors and sleep quality in patients with MDD: A randomized controlled trial study.
Arch Psychiatr Nurs
December 2024
Sleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS), Kermanshah, Iran.
Non-pharmacological interventions are available to improve sleep quality including mindfulness-based stress reduction (MBSR) and physical activity (PA). The present study aimed to evaluate the effectiveness of the combination of MBSR and PA interventions as an augmentation to treatment as usual with sertraline to improve sleep and psychological factors among patients with MDD. Sixty-seven patients in outpatient care diagnosed with MDD for a minimum of 2 months (mean age: 35.
View Article and Find Full Text PDFPlacebo Effects: Neurological Mechanisms Inducing Physiological, Organic, and Belief Responses-A Prospective Analysis.
Healthcare (Basel)
November 2024
College of Pharmacy, University of Illinois, Chicago, IL 60612, USA.
The placebo effect can induce physiological or clinical neurological and organic responses despite the recipient receiving no active ingredients; these responses are based instead on the recipient's perceptions. Placebo effects come from the rostral anterior cingulate cortex, pontine nucleus, and cerebellum of the brain; this information provides a better understanding of placebo effects and can also help us understand the mechanism of the modulation of neurotransmitters from the use of psychedelic substances, activity of selective serotonin reuptake inhibitors, the process of transcranial magnetic stimulation, and deep brain stimulation, as well as aid in developing novel therapies, challenging the validity of controlled clinical trials (RCTs) that the regulatory agencies now appreciate. Education about how placebo effects bring in social, political, and religious beliefs and whether these can be modulated may help reduce global confrontations.
View Article and Find Full Text PDFPatterns, circumstances and risk factors associated with non-fatal substance overdose in a cohort of homeless population: an observational study.
Int J Clin Pharm
November 2024
College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Article Synopsis
- - The study focuses on non-fatal overdoses among homeless individuals, emphasizing that understanding risk factors can help prevent fatal overdoses.
- - Researchers analyzed electronic medical records of 1221 patients, finding that 16% (194 individuals) had experienced a non-fatal overdose, often involving multiple substances like heroin, paracetamol, and benzodiazepines.
- - Key risk factors identified include being female, white, aged 36-45, and having chronic physical or mental health issues, suggesting that targeted prevention strategies could reduce overdose rates, such as providing overdose awareness training and access to naloxone.
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