AI Article Synopsis
- - Tooth agenesis (TA) is a condition where tooth development stops early on and can be classified into two types: non-syndromic (NSTA) and syndromic (STA), based on whether it affects other body systems.
- - Genetic factors are mainly responsible for TA, with many genes, especially WNT10A and EDA, linked to this condition; mutations in these genes are common in cases of NSTA and certain syndromes.
- - The review details what is currently known about the genetic basis of NSTA and STA, particularly looking at how mutations in WNT10A and EDA are connected to the number of teeth that are absent in affected individuals.
Article Abstract
Tooth agenesis (TA) occurs when tooth development is disrupted at the initiation stage. It can be classified into non-syndromic and syndromic forms (named NSTA and STA), depending on whether it is accompanied by abnormalities of other organs and systems. Genetic factors play a predominant role in the pathogenesis of tooth agenesis, with dozens of genes implicated in both forms. Several genes have been identified, mutations in which can lead to both forms of TA. Among these, WNT10A and EDA are frequently mutated genes in this context, representing extensively researched and documented genes in human non-syndromic selective agenesis of permanent teeth and their association with ectodermal dysplasia syndromes. In this review, we present an overview of the current knowledge regarding genes associated with NSTA and STA, focusing on the distribution and nature of WNT10A and EDA gene mutations. We also explore how these mutations relate to the condition's both forms, including their association with the number of missing permanent teeth.
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| http://dx.doi.org/10.1007/s00439-024-02705-x | DOI Listing |
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