AI Article Synopsis
- The study reports two cases of acute retinal necrosis (ARN) caused by co-infection of varicella zoster virus (VZV) and cytomegalovirus (CMV), confirmed through polymerase chain reaction (PCR) testing on aqueous fluid.
- Both patients presented with unilateral panuveitis and underwent empirical therapy; PCR results indicated the dual viral infection, which helped tailor their treatment.
- Follow-up imaging showed resolution of the active retinitis, highlighting the critical role of PCR in diagnosing and managing complicated ARN cases in various patient backgrounds.*
Article Abstract
Purpose: To report the clinical course of two cases of acute retinal necrosis (ARN) caused by varicella zoster virus (VZV) and cytomegalovirus (CMV) co-infection detected by polymerase chain reaction (PCR) on aqueous tap.
Methods: Observational case reports.
Results: Two patients presented to our services with unilateral panuveitis suggestive of ARN complicated by hemorrhagic vasculitis and started empirical therapy. Aqueous PCR was performed on the same day and showed double positivity for VZV and CMV, which guided treatment. At follow-up, wide-field color fundus imaging and high-resolution optical coherence tomography showed resolution of active retinitis.
Conclusion: Our cases suggest that ARN complicated by hemorrhagic vasculitis may be secondary to CMV and VZV co-infection, both in patients with an unremarkable clinical history and in those with immunodeficiency. In our cases, aqueous PCR testing was of paramount importance to determine the aetiology of ARN and to adjust the antiviral therapy accordingly.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/09273948.2024.2404092 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!