Tularemia, caused by Francisella tularensis, is not known to occur in the United Kingdom. We report a case of tularemia diagnosed in July 2023 in a UK patient with no travel in the 6 weeks before symptom onset. We describe the subsequent multiagency investigation into possible routes of acquisition.
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http://dx.doi.org/10.3201/eid3010.240479 | DOI Listing |
Comput Struct Biotechnol J
December 2024
Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, Australia.
In bacteria the formation of disulphide bonds is facilitated by a family of enzymes known as the disulphide bond forming (Dsb) proteins, which, despite low sequence homology, belong to the thioredoxin (TRX) superfamily. Among these enzymes is the disulphide bond-forming protein A (DsbA); a periplasmic thiol oxidase responsible for catalysing the oxidative folding of numerous cell envelope and secreted proteins. Pathogenic bacteria often contain diverse Dsb proteins with distinct functionalities commonly associated with pathogenesis.
View Article and Find Full Text PDFAnimals (Basel)
November 2024
Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), Departamento de Sanidad Animal, UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, 14014 Córdoba, Spain.
is a vector-borne zoonotic bacterium that causes tularemia, a disease of great importance for animal and public health. Although wild lagomorphs are considered one of the major reservoirs of this bacterium, information about the circulation of in European wild rabbit () and Iberian hare () populations in Europe is still very limited. In Spain, is present in northern central regions, with recurrent outbreaks occurring annually.
View Article and Find Full Text PDFFront Microbiol
November 2024
Centre Hospitalier Universitaire Grenoble Alpes, Centre National de Référence Francisella Tularensis, , Grenoble, France.
Tularemia is a re-emerging zoonosis in many endemic countries. It is caused by , a gram-negative bacterium and biological threat agent. Humans are infected from the wild animal reservoir, the environmental reservoir or by the bite of arthropod vectors.
View Article and Find Full Text PDFbioRxiv
November 2024
Department of Cell and Molecular Biology, University of Rhode Island, Kingston, Rhode Island, USA.
Vet Med Sci
January 2025
Department of Chemistry, Environment and Feed Hygiene, SVA, Uppsala, Sweden.
Background: The zoonotic bacterium Francisella tularensis, the causative agent of tularaemia, can be transmitted to humans via multiple routes, including through contact with infected animals, contaminated water or arthropod vectors. Ticks have not previously been described as transmitting the disease in Sweden. Recently, Ixodid tick species have expanded their latitudinal and altitudinal range in Sweden to areas where the disease is endemic.
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