We describe a case of autochthonous human Babesia divergens infection in an immunocompetent woman in England. The patient had fever, hemolysis, multiorgan failure, and 18% parasitemia. We confirmed B. divergens by 18S rDNA PCR and sequencing. Clinicians should consider babesiosis as a differential diagnosis in patients with unexplained hemolysis.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11431931 | PMC |
http://dx.doi.org/10.3201/eid3010.240866 | DOI Listing |
Cureus
November 2024
Internal Medicine, Hospital Conde de Bertiandos, Unidade Local de Saúde do Alto Minho, Ponte de Lima, PRT.
Fascioliasis is a zoonotic disease that may affect humans as incidental hosts after the ingestion of contaminated water or aquatic plants. Despite the non-specificity of its signs and symptoms, a triad of abdominal pain, fever, and peripheral eosinophilia should increase suspicion. The diagnosis of fascioliasis can be particularly difficult in non-endemic countries.
View Article and Find Full Text PDFNature
December 2024
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Focal gene amplifications are among the most common cancer-associated mutations but have proven challenging to engineer in primary cells and model organisms. Here we describe a general strategy to engineer large (more than 1 Mbp) focal amplifications mediated by extrachromosomal DNAs (ecDNAs) in a spatiotemporally controlled manner in cells and in mice. By coupling ecDNA formation with expression of selectable markers, we track the dynamics of ecDNA-containing cells under physiological conditions and in the presence of specific selective pressures.
View Article and Find Full Text PDFSci Transl Med
December 2024
State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Tumors occurring along the hypothalamus-pituitary axis receive axonal projection from neuroendocrine neurons, but it remains unclear whether neuroendocrine neuronal activity drives tumor expansion. Craniopharyngioma is a common suprasellar tumor with a propensity for invading the hypothalamus, leading to devastating endocrine and metabolic disorders. Here, we developed two autochthonous animal models that faithfully recapitulate the molecular pathology, clinical manifestations, and transcriptomic profiles of papillary craniopharyngioma.
View Article and Find Full Text PDFMedicina (B Aires)
December 2024
Departamento de Bacteriología, Servicio Bacteriología Especial, INEI-ANLIS Carlos G. Mabrán, Buenos Aires, Argentina.
Introduction: Lyme disease (LD) is caused by bacteria of the Borrelia burgdorferi sensu lato complex and transmitted by the bite of ticks of the Ixodes ricinus complex. To date, no autochthonous cases have been reported in Argentina. Its diagnosis involves serological tests included in a two-step algorithm.
View Article and Find Full Text PDFFront Vet Sci
November 2024
Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.
Hepatitis E virus (HEV) is recognized as an emerging zoonosis. Pigs and wild boars are considered the main reservoirs of zoonotic HEV-3 and HEV-4 genotypes. In Europe, autochthonous human cases of hepatitis E, mainly associated with HEV-3 and consumption of raw or undercooked pig and wild boar liver/meat, have increased over the last decades.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!