AI Article Synopsis
- The study by Collaço et al. explores the inhibitory effects of ω-grammotoxin-SIA on various voltage-gated ion channels.
- In addition to its known impact on calcium (Ca2+) and potassium (K+) channels, the toxin also inhibits voltaged-gated sodium (Na+) channel currents.
- These findings suggest that ω-grammotoxin-SIA has a broader effect on ion channel activity than previously understood, which could have implications for understanding its biological roles.
Article Abstract
This JGP study (Collaço et al. https://doi.org/10.1085/jgp.202413563) reveals that in addition to voltage-gated Ca2+ and K+ channels, ω-grammotoxin-SIA also inhibits voltage-gated Na+ channel currents.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449121 | PMC |
| http://dx.doi.org/10.1085/jgp.202413665 | DOI Listing |
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