AI Article Synopsis
- The study aimed to identify factors predicting ongoing driving risks related to sleepiness in patients with obstructive sleep apnea (OSA) undergoing continuous positive airway pressure (CPAP) treatment.
- Researchers analyzed data from over 5,300 patients, assessing incidents of near-misses and accidents before and after at least 90 days of CPAP therapy.
- Findings revealed that ongoing sleepiness while driving and poor treatment adherence (less than 4 hours per night) significantly increased the likelihood of near-misses and accidents, highlighting the need for thorough follow-ups by health professionals.
Article Abstract
Study Objectives: To investigate the predictors of persistent driving risk related to sleepiness in patients with obstructive sleep apnea syndrome (OSAS) treated by continuous positive airway pressure (CPAP).
Methods: Longitudinal analysis of a prospective national database including 5308 patients with OSAS and an indication of CPAP. Near misses related to sleepiness, accidents related to sleepiness, and sleepiness at the wheel (SAW) were assessed before initiation and after ≥90 days of treatment. Multivariable associations with the cumulative incidence of near-misses and accidents under treatment were calculated using Cox models adjusted for age, sex, obesity, sleep duration, SAW, accidents/near-misses history, depressive symptoms, residual apnea-hypopnea index, and adherence to treatment.
Results: Residual SAW under treatment was associated with an eight-fold higher incidence of near-misses related to sleepiness (hazard ratios [HR] = 8.63 [6.08-12.2]) and five-fold higher incidence of accidents related to sleepiness (HR = 5.24 [2.81-9.78]). Adherence ≤4 h/night was also a significant predictor of persistent driving risk (HR = 1.74 [1.12-2.71] for near-misses and HR = 3.20 [1.37-7.49] for accidents).
Conclusions: Residual SAW and treatment adherence ≤4 h/night are easy-to-assess markers to detect persistent driving risk during the follow-up evaluations of patients under treatment. Health professionals, but also policymakers, should be aware of the crucial importance of systematically evaluating these elements during the follow-up evaluations of the patients with OSAS treated by CPAP to better evaluate their driving risk.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/sleep/zsae211 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Advanced Markers for Hemodynamic Monitoring in Cardiogenic Shock and End-Stage Heart Failure: A Mini Review.
Heart Fail Rev
January 2025
Division of Cardiovascular Medicine, University of Utah Health & School of Medicine, 30 N Mario Capecchi Drive, HELIX Building 3rd Floor, Salt Lake City, UT, 84112, USA.
Right heart catheterization (RHC) provides critical hemodynamic insights by measuring atrial, ventricular, and pulmonary artery pressures, as well as cardiac output (CO). Although the use of RHC has decreased, its application has been linked to improved outcomes. Advanced hemodynamic markers such as cardiac power output (CPO), aortic pulsatility index (API), pulmonary artery pulsatility index (PAPi), right atrial pressure to pulmonary capillary wedge pressure ratio (RAP/PCWP) and right ventricular stroke work index (RVSWI) have been introduced to enhance risk stratification in cardiogenic shock (CS) and end-stage heart failure (HF) patients.
View Article and Find Full Text PDFAn Overview of Invasive Ductal Carcinoma (IDC) in Women's Breast Cancer.
Curr Mol Med
January 2025
Division of Biological and Health Sciences, University of Pittsburgh, 300 Campus Drive, Bradford PA 16701.
Invasive ductal carcinoma (IDC) is the most common type of breast cancer, primarily affecting women in the United States and across the world. This review summarizes key concepts related to IDC causes, treatment approaches, and the identification of biological markers for specific prognoses. Furthermore, we reviewed many studies, including those involving patients with IDC and ductal carcinoma in situ (DCIS) that progressed to IDC.
View Article and Find Full Text PDFPoorer objective but not subjective driving performance in drivers vulnerable to sleep loss effects during extended wake.
J Sleep Res
January 2025
Flinders Health and Medical Research Institute: Sleep Health, Flinders University, Adelaide, South Australia, Australia.
Sleepiness-related errors are a leading cause of driving accidents, requiring drivers to effectively monitor sleepiness levels. However, there are inter-individual differences in driving performance after sleep loss, with some showing poor driving performance while others show minimal impairment. This research explored if there are differences in self-reported sleepiness and driving performance in healthy drivers who exhibited vulnerability or resistance to objective driving impairment following extended wakefulness.
View Article and Find Full Text PDFVentilator-Associated Pneumonia in Low- and Middle-Income vs. High-Income Countries: The Role of Ventilator Bundle, Ventilation Practices, and Healthcare Staffing.
Chest
January 2025
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Electronic address:
Background: Ventilator-associated pneumonia (VAP) rates are higher in low- and middle-income countries (LMICs) than in high-income countries (HICs).
Research Question: Could differences in ventilator bundle adherence, ventilation practices, and critical care staffing be driving variations in VAP risk between LMICs and HICs?
Study Design And Methods: This secondary analysis of the multicenter, international CERTAIN study included mechanically ventilated patients at risk for VAP from eleven LMICs and five HICs. We included oral care, head-of-bed elevation, spontaneous breathing assessments, and sedation breaks in the ventilator bundle.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!