AI Article Synopsis
- Post-coronavirus disease condition (PCC) continues to impact many people, but there's a lack of reliable diagnostic biomarkers to differentiate it from recovery after acute COVID-19.
- A study compared biomarkers between two groups: people with PCC and those who recovered from COVID-19 within three months, both consisting of 85 individuals.
- The results showed PCC individuals had significant changes in 49 out of 167 markers, and a specific panel of four biomarkers could distinguish PCC from recovery with over 88% accuracy.
Article Abstract
Post-coronavirus disease condition (PCC) continues to affect many people globally, yet there remains a lack of diagnostic biomarkers to distinguish PCC from those recovered from acute COVID-19. This study compared biomarkers between two age- and gender-matched groups: PCC individuals and those recovered within three months of acute COVID-19 in 2020 ( = 85 each). Biomarkers were assessed 12-24 months after initial diagnosis, examining biochemical profiles, blood cell counts, coagulation status, antibody serology, lymphocyte populations, and cytokine levels. PCC individuals exhibited significant alterations in 49 of 167 markers, including K+ levels, αGAD antibodies, antithrombin III, insulin-like growth factor-binding protein 3 (IGFBP3), and interleukin-10 (IL-10). A panel of αGAD, IL-10, potassium levels, and CD16CD56 cell presence distinguished PCC individuals from recovered patients with >88% accuracy and <92% precision.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420445 | PMC |
| http://dx.doi.org/10.1016/j.isci.2024.110839 | DOI Listing |
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