We report a dual transition metal electrocatalytic approach for C(sp)-C(sp) bond cleavage and arylation of cyclic alcohols, providing an efficient and sustainable method for site-specific arylation of ketones. The reaction involves electrophotochemical cerium-catalysed generation of alkoxyl radicals from readily accessible alcohols. Subsequently, homolytic cleavage of the β-C-C bond leads to the generation of carbon-centered radicals that could be effectively utilized by nickel catalysis powered by cathode reduction to deliver the remote arylated ketone products.
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| http://dx.doi.org/10.1039/d4cc04036h | DOI Listing |
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