Objective: To correlate temporomandibular joint (TMJ) morphology and position with cone-beam computed tomography (CBCT) images, Joint Vibration Analysis (JVA), and Jaw Tracker (JT) to develop a radiation-free, dynamic method for screening and monitoring the TMJ in orthodontic patients.
Methods: A total of 236 orthodontic patients without symptoms of TMJ disorders who had undergone CBCT were selected for the JVA and JT tests in this cross-sectional study. TMJ position and morphology were measured using a three-dimensional analysis software. JT measurements involved six opening-closing cycles, and JVA measurements were performed using a metronome to guide the mouth opening-closing movements of the patients. The correlations among the three measuring devices were evaluated.
Results: Abnormalities in condylar surface morphology affected the mandibular range of motion. The cut-off value results show that when various measurement groups are within a certain range, abnormalities may be observed in morphology (area under the curve, 0.81; < 0.001). A 300/< 300 Hz ratio ≥ 0.09 suggested abnormal morphology ( < 0.05). Correlations were observed among the maximum opening velocity, maximum vertical opening position, and joint spaces in the JT measurements. Correlations were also observed between the > 300/< 300 Hz ratio, median frequency, total integral, integral < 300 Hz, and peak frequency with joint spaces in the JVA measurements.
Conclusions: JT and JVA may serve as rapid, non-invasive, and radiation-free dynamic diagnostic tools for monitoring and screening TMJ abnormalities before and during orthodontic treatment.
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http://dx.doi.org/10.4041/kjod24.089 | DOI Listing |
Front Physiol
December 2024
Department of Oral & Maxillofacial Surgery, Shenzhen Stomatology Hospital, Affiliated to Shenzhen University, Shenzhen, Guangdong Province, China.
Introduction: This study aimed to develop a deep learning-based method for interpreting magnetic resonance imaging (MRI) scans of temporomandibular joint (TMJ) anterior disc displacement (ADD) and to formulate an automated diagnostic system for clinical practice.
Methods: The deep learning models were utilized to identify regions of interest (ROI), segment TMJ structures including the articular disc, condyle, glenoid fossa, and articular tubercle, and classify TMJ ADD. The models employed Grad-CAM heatmaps and segmentation annotation diagrams for visual diagnostic predictions and were deployed for clinical application.
J Oral Rehabil
December 2024
Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, China.
Background: Anterior disc displacement (ADD) is the most common type of temporomandibular joint (TMJ) internal derangement and may lead to condylar resorption (CR) during the adolescence period, but the specific malocclusion associated with ADD and CR remains unclear.
Objective: This study aimed to investigate the malocclusion associated with TMJ ADD and CR in adolescents.
Methods: This cross-sectional study included a clinical examination of adolescent patients aged 11-19 years.
J Craniofac Surg
October 2024
Department of Maxillofacial Surgery, Hospital del Salvador, Santiago, Chile.
Condylar hyperplasia (CH) is a complex, usually unilateral pathology affecting the jaw, leading to facial asymmetry and malocclusion. Its etiology is unclear, with potential links to endocrine disorders, trauma, and genetic factors. Unilateral condylar hyperplasia (UCH) typically presents in young patients but can occur at any age.
View Article and Find Full Text PDFOsteoarthritis Cartilage
December 2024
Department of Oral Anatomy and Physiology and TMD, College of Stomatology, the Fourth Military Medical University. Xi'an, China; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai, China. Electronic address:
Objective: Abnormal mechanical stress is intimately coupled with osteoarthritis (OA). Microtubules play a vital role in the regulation of mechanotransduction and intracellular transport. The purpose of the present study was to investigate the impact of stress-induced microtubule impairment on intracellular transport and lipid droplet (LD) accumulation in chondrocytes.
View Article and Find Full Text PDFOsteoarthritis Cartilage
December 2024
Department of Oral Anatomy and Physiology and TMD, College of Stomatology, the Fourth Military Medical University. Xi'an, China; Department of Oral anatomy and Physiology and TMD, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China. Electronic address:
Objective: Some cells in temporomandibular joint (TMJ) cartilage undergo proliferation in response to negative pressure, which can be induced in vivo by creating bilateral anterior elevation (BAE). TMJ cartilage harbours CD90-expressing cells, and CD90 expression increases under certain controlled conditions. The parathyroid hormone-related peptide (PTHrP) nuclear localization segment (NLS) promotes chondrocyte proliferation, and mammalian target of rapamycin (mTOR) signalling plays a regulatory role in promoting PTHrP transcription.
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