AI Article Synopsis
- Feedback at the photoreceptor synapse plays a crucial role in visual processing by influencing how visual signals are processed in the brain.
- Researchers found that the electrogenic bicarbonate transporter Slc4a5 in mouse horizontal cells is essential for this feedback, while another transporter, Slc4a3, is not involved.
- Their findings suggest that changes in the voltage of horizontal cells affect bicarbonate transport to cones, indicating a unique mechanism at this initial stage of visual synapse activity.
Article Abstract
Feedback at the photoreceptor synapse is the first neuronal circuit computation in vision, which influences downstream activity patterns within the visual system. Yet, the identity of the feedback signal and the mechanism of synaptic transmission are still not well understood. Here, we combined perturbations of cell-type-specific genes of mouse horizontal cells with two-photon imaging of the result of light-induced feedback in cones and showed that the electrogenic bicarbonate transporter Slc4a5, but not the electroneutral bicarbonate transporter Slc4a3, both expressed specifically in horizontal cells, is necessary for horizontal cell-to-cone feedback. Pharmacological blockage of bicarbonate transporters and buffering pH also abolished the feedback but blocking sodium-proton exchangers and GABA receptors did not. Our work suggests an unconventional mechanism of feedback at the first visual synapse: changes in horizontal cell voltage modulate bicarbonate transport to the cell, via Slc4a5, which leads to the modulation of feedback to cones.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602199 | PMC |
| http://dx.doi.org/10.1016/j.neuron.2024.08.015 | DOI Listing |
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