Background: People aging with HIV (PAWH) experience greater impairment in physical and pulmonary function than individuals aging without HIV. We examined whether baseline physical function was associated with subsequent pulmonary impairments.
Methods: Associations of frailty and physical function (gait speed [m/sec], grip strength [kg]) with pulmonary function (< 80% predicted diffusing capacity for carbon monoxide [DL] and forced expiratory volume [FEV]) 3 years later were modeled; age, HIV status, and smoking were assessed as effect modifiers.
Results: Among1,024 men, (54% PAWH, 10% frail, 51% pre-frail), mean (SD) age = 53 (12) years, cumulative smoking = 12 (19) pack-years, gait speed = 1.1 (0.2) m/sec, and grip strength = 36.6 (9.2) kg. Frailty, pre-frailty, and weak grip strength were associated with higher odds of subsequent impaired DL and FEV. Slow gait speed was associated with higher odds of DL impairment but not FEV. No statistically significant modifications were found.
Conclusion: Interventions to improve physical function may help preserve pulmonary function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419174 | PMC |
| http://dx.doi.org/10.21203/rs.3.rs-4908040/v1 | DOI Listing |
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