AI Article Synopsis
- A large genomic study on African malaria isolates was conducted, analyzing 77 samples from Cameroon, the Democratic Republic of the Congo, Nigeria, and Tanzania collected between 2015 and 2021.
- The study found no geographic population structure among the isolates, indicating that they are panmictic and mixing freely across different regions.
- While there were no clear indicators of significant resistance genes, certain erythrocyte invasion ligands and antimalarial resistance markers showed signs of selective pressure, suggesting that the malaria population is recovering from a past decline.
Article Abstract
is geographically widespread but neglected and may become more prevalent as declines. We completed the largest genomic study of African to-date by performing hybrid capture and sequencing of 77 isolates from Cameroon (n=7), the Democratic Republic of the Congo (n=16), Nigeria (n=4), and Tanzania (n=50) collected between 2015 and 2021. There is no evidence of geographic population structure. Nucleotide diversity was significantly lower than in co-localized isolates, while linkage disequilibrium was significantly higher. Genome-wide selection scans identified no erythrocyte invasion ligands or antimalarial resistance orthologs as top hits; however, targeted analyses of these loci revealed evidence of selective sweeps around four erythrocyte invasion ligands and six antimalarial resistance orthologs. Demographic inference modeling suggests that African is recovering from a bottleneck. Altogether, these results suggest that is genomically atypical among human spp. and panmictic in Africa.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11419228 | PMC |
| http://dx.doi.org/10.1101/2024.09.07.24313132 | DOI Listing |
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