AI Article Synopsis
- Aging of the face involves complex three-dimensional changes across five layers of facial anatomy, influenced by various factors over time.
- New research has identified key structures and led to the development of pharmacologic agents aimed at reversing signs of aging, alongside traditional treatments like botulinum toxin and fillers.
- Effective antiaging treatments require a deep understanding of the aging process and should be personalized based on individual patient characteristics and desired outcomes.
Article Abstract
Aging of the face is the result of the interrelation of three-dimensional changes occurring over time among the 5 different layers of the face and its associated structures. Knowledge regarding the causes of these changes and identification of new key anatomic structures have helped elucidate one of the most complex areas of the human body. This has resulted in the introduction of pharmacologic agents to help stop, mitigate, or counteract signs of aging and restore the youthful appearance of the face. The authors performed a systematic search of the literature to review the current highest-level evidence of facial antiaging pharmacologic agents. Pharmacologic and minimally invasive antiaging treatments can target different components of facial aging and continue to evolve. With continuous research efforts, traditional treatments, such as botulinum toxin type A, injectable fillers, and chemical peels, are emerging in newer, more effective formulations, with longer lasting clinical results. However, for soft-tissue descent and facial volume loss, surgery remains the standard treatment. An adequate understanding of the three-dimensional process of facial aging over time (the fourth dimension), facial anatomy, and the pharmacologic properties of antiaging/rejuvenation agents are the sine qua non of facial antiaging treatment. The specific modality should be tailored to patient characteristics, preferences, and goals.
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| http://dx.doi.org/10.1097/PRS.0000000000010767 | DOI Listing |
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