Granulomatosis with polyangiitis (GPA), formerly Wegener's granulomatosis, commonly presents primarily with otitis media and hearing loss, as well as upper and lower respiratory symptoms. However, facial nerve paralysis is a rare manifestation of this uncommon necrotizing vasculitis. We report a patient with facial paralysis accompanied by otitis media. In further studies, our patient was diagnosed with GPA, which was neglected before. In such a presentation, acute suppurative otitis media is the most likely cause of the facial paralysis, but GPA must also be considered, especially in cases with new-onset, painful serous otitis, acute otitis media, or pale granulation tissue in the middle ear, in adults with no previous history of Eustachian tube dysfunction.
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http://dx.doi.org/10.1177/01455613241272669 | DOI Listing |
Acta Otorhinolaryngol Ital
December 2024
Faculty of Medicine and Surgery, University of Enna "Kore", Enna, Italy.
Objectives: Chronic otitis media (COM) is a prevalent condition affecting auditory function. Ossiculoplasty is a known treatment strategy, but its effectiveness concerning the presence of cholesteatoma has not been extensively studied.
Methods: We conducted a multicentre study involving 153 patients diagnosed with COM without cholesteatoma (ncCOM) and with cholesteatoma (cCOM).
JAMA Netw Open
January 2025
Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Importance: A high infection burden in early childhood is common and a risk factor for later disease development. However, longitudinal birth cohort studies investigating early-life infection burden and later risk of infection and antibiotic episodes are lacking.
Objective: To investigate whether early-life infection burden is associated with a later risk of infection and systemic antibiotic treatment episodes in childhood.
Cureus
December 2024
Otolaryngology - Head and Neck Surgery, Varun Arjun Medical College & Rohilkhand Hospital, Shahjahanpur, IND.
Objective: Chronic otitis media (COM) is characterized by chronic, intermittent, or persistent discharge through a perforated tympanic membrane. In this study, we aimed to evaluate the postoperative audiological outcomes in middle-aged patients compared to younger patients who underwent tympanoplasty with mastoidectomy via post-auricular approach for the treatment of COM.
Methods: This prospective interventional study included patients admitted in wards from August 2017 to January 2019 at the Department of Otorhinolaryngology, Jawaharlal Nehru Medical College and Hospital, Aligarh, India.
Cureus
January 2025
Department of Microbiology, Medical University-Sofia, Sofia, BGR.
Facial paralysis is an infrequent and serious potential complication of acute otitis media (AOM). We describe a pediatric case of rapidly progressive facial paralysis as a secondary complication alongside AOM, caused by the non-typeable (NTHi) strain, which was managed with facial nerve decompression, glucocorticoid medication, and antimicrobial chemotherapy. The reasons why NTHi becomes pathogenic in certain patients are not yet fully understood, and the specific interactions and adaptations that lead to complications must be further investigated, as they result in more complex treatment approaches.
View Article and Find Full Text PDFBraz J Otorhinolaryngol
January 2025
Tokushima University Graduate School, Institute of Biomedical Sciences, Department of Otolaryngology-Head and Neck Surgery, Tokushima, Japan.
Objective: Eosinophilic Otitis Media (EOM) is an intractable disease caused by type 2 inflammation, such as Eosinophilic Chronic Rhinosinusitis (ECRS) and bronchial asthma. Biologics have recently been used to treat ECRS and bronchial asthma. Biologics are not indicated for EOM; however, because approximately 10% of ECRS cases has concomitant EOM, concomitant EOM improvement has been observed when dupilumab is administered for ECRS.
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