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Coronary Artery Calcium Scores After Prophylactic Premenopausal Bilateral Salpingo-Oophorectomy.
JACC CardioOncol
December 2024
The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Background: Premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at high familial risk of ovarian cancer leads to immediate menopause. Although early natural menopause is associated with increased cardiovascular disease risk, evidence on long-term cardiovascular disease risk after early surgical menopause is scarce.
Objectives: We sought to determine the long-term influence of the timing of RRSO on the development of coronary artery calcium (CAC), an established marker for cardiovascular disease risk.
[Early Recurrence of Triple Negative Breast Cancer with Pathological Complete Response Following Neoadjuvant Chemotherapy and a Poor Prognosis-A Case Report].
Gan To Kagaku Ryoho
December 2024
Breast Center, Kochi Medical School Hospital.
In this study, we report the case of a patient with triple-negative breast cancer who achieved a pathological complete response(pCR)following neoadjuvant chemotherapy but experienced early recurrence and had a poor prognosis. A 46-year-old woman with a diagnosis of triple-negative breast cancer(cT2cN3cM0, cStage ⅢC)received neoadjuvant chemotherapy with dose-dense doxorubicin and cyclophosphamide, followed by weekly paclitaxel. The patient underwent a mastectomy and axillary lymph node dissection, achieving pCR.
View Article and Find Full Text PDFUptake of Risk-Reducing Salpingo-Oophorectomy and Gynaecologic Surveillance Among Germline BRCA Pathogenic Variants Carriers.
Cancer Med
December 2024
Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
Article Synopsis
- Risk-reducing salpingo-oophorectomy (RRSO) is recommended for women with BRCA1/2 pathogenic variants to prevent ovarian cancer, but many still refuse the surgery despite its benefits.
- A study at a referral center in Italy analyzed 287 women, finding a high uptake rate of 96.1% for RRSO after counseling, although some women were hesitant due to fears about menopause and childbearing.
- The study suggests that a specialized clinic with a supportive team and options for surveillance plays a crucial role in encouraging women to consider risk-reducing surgery.
Pattern Anlysis of Risk-Reducing Strategies in Unaffected Korean Mutation Carriers.
Curr Oncol
November 2024
Department of Surgery, Daerim St. Mary's Hospital, Seoul 07442, Republic of Korea.
The lifetime risk of breast and ovarian cancer increases substantially for individuals with mutations in . The evidence indicates that mutation carriers benefit from early cancer detection and prevention strategies. However, data on the patterns of risk-reducing interventions are lacking.
View Article and Find Full Text PDFHigh-grade serous carcinoma occurring after risk-reducing salpingo-oophorectomy in BRCA1/2 germline pathogenic variant carriers.
J Natl Cancer Inst
November 2024
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Article Synopsis
- Risk-reducing salpingo-oophorectomy (RRSO) significantly lowers the risk of high-grade serous carcinoma (HGSC) in women carrying BRCA1/2 genetic variants, but some still develop HGSC after the procedure.
- A study involving 2,519 women found that the 20-year cumulative incidence of HGSC was low (1.5% for BRCA1 and 0.2% for BRCA2 carriers), with particular risk factors identified, such as older age at RRSO and incomplete embedding of RRSO specimens.
- Implementing strict guidelines for timely RRSO and ensuring complete specimen embedding could further minimize the risk of developing HGSC in these patients
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