AI Article Synopsis
- The study investigates immune checkpoint inhibitor-associated pneumonitis (CIP) in non-small cell lung cancer (NSCLC) patients receiving anti-PD-1 therapy, aiming to identify risk factors and their impact on prognosis.
- Out of 229 patients analyzed, 15.3% experienced CIP, with higher occurrences among males and those with prior smoking or lung disease; elevated CD4 T lymphocytes and AEC were found to be significant predictors of CIP.
- The presence of CIP was linked to improved progression-free survival and better treatment efficacy, highlighting the necessity for early detection and intervention.
Article Abstract
Introduction: Immune checkpoint inhibitor-associated pneumonitis (CIP) is the most common immune-related advanced event (irAE). However, the risk factors of CIP occurrence and its relationship with prognosis remain to be clarified. This study aimed to explore biomarkers, prognosis, and efficacy of CIP occurrence in non-small cell lung cancer (NSCLC) patients who received anti-PD-1 inhibitors.
Methods: We performed a retrospective study in eligible NSCLC patients treated with anti-PD-1 inhibitors in Ruijin hospital. The receiver operating characteristic (ROC) curve and logistic regression were used for the optional cut-off value and the risk of CIP, respectively. The Kaplan-Meier method and Cox hazards regression models were used for survival analyses in CIP and non-CIP groups.
Results: Our study enrolled 229 patients, of which 35 (15.3 %) experienced CIP. CIP patients had higher proportions of male, current and former smoking, and history of pre-existing lung diseases. CIP patients also had a higher level of WBC (p = 0.025), ANC (p = 0.020), AEC (p = 0.025), and proportion of CD4 T lymphocytes (p = 0.033) than those in non-CIP patients. Then patients were divided into two groups according to the cutoff value. It showed high baseline proportion of CD4 T lymphocytes (OR = 4.027 (1.279-12.677), P = 0.017) and AEC (OR = 2.697 (1.047-6.945, P = 0.040) were independent predictors of CIP occurrence. CIP occurrence was an independent predictor of progression-free survival (PFS) in the enrolled patients. Regarding patient efficacy, severe-CIP patients had the highest ORR, followed by grade 1-2 CIP patients, and non-CIP patients (44.44 %, 35.3 %, and 28.35 %, respectively).
Conclusion: The onset time of CIP occurrence was early in severe CIP patients, suggesting the importance of early identification and timely intervention of CIP. Baseline proportion of CD4 T lymphocytes and AEC were independent predictors of CIP occurrence. In addition, CIP occurrence predicted higher ORR, longer PFS, and more opportunities for long-term survival benefits.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.intimp.2024.113140 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Detection and Characterisation of Colistin-Resistant in Broiler Meats.
Microorganisms
December 2024
Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University, Chattogram 4225, Bangladesh.
The irrational use of antimicrobials has led to the emergence of resistance, impacting not only pathogenic bacteria but also commensal bacteria. Resistance against colistin, a last-resort antibiotic, mediated by globally disseminated plasmid-borne mobile colistin resistance () genes, has raised significant global concerns. This cross-sectional study aimed to investigate the antimicrobial resistance patterns of colistin-resistant () and mobilised colistin resistance ( 1-5) genes from broiler meat.
View Article and Find Full Text PDFInsight into the effect of ZIF-8 on the interaction between drugs and protein/cell.
Int J Biol Macromol
January 2025
School of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, China. Electronic address:
Understanding the impact of nanomaterials on drug-protein/cell interactions is crucial for comprehending their in vivo biological effects. We investigated the impact of zeolitic imidazolate framework (ZIF)-8 on the interaction between curcumin (Cur) and human serum albumin (HSA) using various spectroscopic techniques and molecular docking. Additionally, we examined its effect on drug-cell interaction using HepG2 cells and Escherichia coli (E.
View Article and Find Full Text PDFPrognostic factors for transplant-free survival in patients with secondary sclerosing cholangitis associated with critical illness.
BMJ Open Gastroenterol
January 2025
Department of Gastroenterology, Hepatology and Transplant Medicine, University of Duisburg-Essen, Essen, Germany
Objective: Secondary sclerosing cholangitis (SSC) represents a disease with a poor prognosis increasingly diagnosed in clinical settings. Notably, SSC in critically ill patients (SSC-CIP) is the most frequent cause. Variables associated with worse prognosis remain unclear.
View Article and Find Full Text PDFThe impact of antioxidant-ciprofloxacin combinations on the evolution of antibiotic resistance in Pseudomonas aeruginosa biofilms.
NPJ Biofilms Microbiomes
December 2024
Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, 2200, Denmark.
The evolution of antimicrobial resistance (AMR) in biofilms, driven by mechanisms like oxidative stress, is a major challenge. This study investigates whether antioxidants (AOs) such as N-acetyl-cysteine (NAC) and Edaravone (ED) can reduce AMR in Pseudomonas aeruginosa biofilms exposed to sub-inhibitory concentrations of ciprofloxacin (CIP). In vitro experimental evolution studies were conducted using flow cells and glass beads biofilm models.
View Article and Find Full Text PDFOccurrence and ecological risks of antibiotics and antiparasitics in surface water in urban lakes in Hanoi city, Vietnam.
Environ Sci Pollut Res Int
January 2025
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay, Hanoi, Vietnam.
The presence of antibiotics in the environment is of significant concern due to their adverse effects on aquatic ecosystems. This study provides an assessment of potential ecological risks (RQ) associated with the concentrations of eight antibiotics and antiparasitics (amoxicillin-AMO, azithromycin-AZI, ciprofloxacine-CIP, ofloxacine-OFL, oxfendazole-OXF, lincomycin-LIN, sulfacetamide-SCE and sulfamethoxazole-SME) in the surface water of 13 urban lakes in Hanoi city, Vietnam during the period 2021-2023. The findings revealed considerable variations in the total concentrations of these 8 substances (T), ranging from below the method detection limit (< MDL) to 2240 ng L with an average of 330.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!