Introduction: The presence of pre-existing autoimmune disease (PAD) with metastatic non-small cell lung cancer (mNSCLC) poses challenges in the use of immune checkpoint inhibitors (ICI). This study investigated factors influencing ICI utilization in older adults with mNSCLC and PAD.
Materials And Methods: A retrospective cohort study with a 12-month baseline prior to treatment initiation was conducted using the SEER-Medicare data. Patients aged 66 years and above diagnosed with mNSCLC between January 2015 and December 2017, who initiated immunotherapy only/chemoimmunotherapy (IT/CIT) or chemotherapy only (CIT) and had at least one PAD diagnosed any time before treatment initiation, were included. Multiple factors, guided by the Model of Health Services Utilization, were analyzed using multivariable logistic regression. Adjusted odds ratios (aORs) and 95.0% CIs were reported.
Results: Among 1,319 patients initiating first-line (1L) systemic therapy, 22.3% received IT/CIT and 77.7% received CT. Patients initiating IT/CIT were more likely to be 76-80 years old (aOR = 1.70, 95.0% CI = 1.02-2.81) and > 80 years old (aOR = 2.49, 95.0% CI = 1.46-4.25), reside in South (aOR = 2.32, 95.0% CI = 1.36-3.96) and West (aOR = 2.27, 95.0% CI = 1.44-3.60) SEER regions, diagnosed in 2016 (aOR = 6.36, 95.0% CI = 3.06-13.22) and 2017 (aOR = 40.45, 95.0% CI = 19.70-83.07), having a longer time to treatment initiation (aOR = 1.14, 95.0% CI = 1.08-1.19), having non-squamous tumor histology (aOR = 1.511, 95.0% CI = 1.048-2.179), and having a prior hospitalization (aOR = 1.63, 95.0% CI = 1.14-2.33). These patients were less likely to have recently used an immunosuppressant (IS) (aOR = 0.06, 95.0% CI = 0.04-0.10).
Discussion: Several factors, such as age, region, cancer diagnosis year, time to treatment initiation, and recent IS use, intricately shape treatment decisions. Further in-depth research on each of these factors is imperative to optimize strategies for this distinctive patient population.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jgo.2024.102071 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Crucial Role of Aluminium-Regulated Flavonol Glycosides (F2-Type) Biosynthesis in Lateral Root Formation of Camellia sinensis.
Plant Cell Environ
January 2025
State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China.
In acidic soil conditions, aluminium (Al) limits crop growth and yields but benefits the growth of tea plants. Flavonols are suggested to form complexes with Al, enhancing Al accumulation in tea plants. The role of flavonols in promoting lateral root formation under Al stress remains unclear.
View Article and Find Full Text PDFImpact of dietary lysophospholipids supplementation on growth performance, meat quality, and lipid metabolism in finishing bulls fed diets varying in fatty acid saturation.
J Anim Sci Biotechnol
January 2025
College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People's Republic of China.
Background: The objective of this study was to evaluate the effects of dietary fatty acids (FA) saturation and lysophospholipids supplementation on growth, meat quality, oxidative stability, FA profiles, and lipid metabolism of finishing beef bulls. Thirty-two Angus bulls (initial body weight: 623 ± 22.6 kg; 21 ± 0.
View Article and Find Full Text PDFSecreted LGALS3BP facilitates distant metastasis of breast cancer.
Breast Cancer Res
January 2025
College of Pharmacy, Seoul National University, Seoul, 08826, South Korea.
Background: Patients with estrogen receptor (ER)-positive breast cancer (BC) can be treated with endocrine therapy targeting ER, however, metastatic recurrence occurs in 25% of the patients who have initially been treated. Secreted proteins from tumors play important roles in cancer metastasis but previous methods for isolating secretory proteins had limitations in identifying novel targets.
Methods: We applied an in situ secretory protein labeling technique using TurboID to analyze secretome from tamoxifen-resistant (TAMR) BC.
Background: Antibiomania is the manifestation of manic symptoms secondary to taking an antibiotic, which is a rare side effect. In these cases, the antibiotics most often incriminated are macrolides and quinolones, but to our knowledge, there are no published cases of antibiomania secondary to cotrimoxazole. Furthermore, we also provide an update of pharmacovigilance data concerning antibiomania through a search of the World Health Organization (WHO) database.
View Article and Find Full Text PDFA novel homozygous intronic variant in CDT1 that alters splicing causes Meier-Gorlin syndrome, and a review of published mutations and growth hormone treatments.
Orphanet J Rare Dis
December 2024
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Meier-Gorlin syndrome (MGORS) is a rare autosomal inherited form of primordial dwarfism. Pathogenic variants in 13 genes involved in DNA replication initiation have been identified in this disease, but homozygous intronic variants have never been reported. Additionally, whether growth hormone (GH) treatment can increase the height of children with MGORS is unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!