AI Article Synopsis
- Stem cells exist in a dormant state within various tissues and can differentiate into new cells when needed, with mesenchymal stem cells being notable for their potential in tissue regeneration and immunomodulation.
- They release substances like paracrine factors and exosomes, which have various benefits such as reducing inflammation and promoting healing, indicating their importance in cell therapy and regenerative medicine.
- Aging hampers stem cells' ability to self-renew and differentiate, limiting regeneration, but advancements in therapy guidelines and clinical trials suggest that stem cell transplantation could be vital for combating age-related tissue damage.
Article Abstract
Stem cells are present in the tissues and organs and remain in a quiescent and undifferentiated state until it is physiologically necessary to produce new descendant cells. Due to their multipotency property, mesenchymal stem cells have attracted considerable attention worldwide due to their immunomodulation and therapeutic function in tissue regeneration. Stem cells secrete components such as paracrine factors, extracellular vesicles, and exosomes which have been shown to have anti-inflammatory, anti-aging, reconstruction and wound healing potentials in many and models. The pluripotency and immunomodulatory features of stem cells could potentially be an effective tool in cell therapy and tissue repair. Aging affects the capacity for self-renewal and differentiation of stem cells, decreasing the potential for regeneration and the loss of optimal functions in organisms over time. Current progress in the field of cellular therapy and regenerative medicine has facilitated the evolution of particular guidelines and quality control approaches, which eventually lead to clinical trials. Cell therapy could potentially be one of the most promising therapies to control aging due to the fact that single stem cell transplantation can regenerate or substitute the injured tissue. To understand the involvement of stem cells not only in tissue maintenance and disease but also in the control of aging it is important to know and identify their properties, functions, and regulation , which are addressed in this review.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372738 | PMC |
| http://dx.doi.org/10.5493/wjem.v14.i3.97233 | DOI Listing |
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