Marine sponges are valuable sources of bioactive compounds, which have attracted pharmacological interest. This study aimed to evaluate the chemical profile, antioxidant, and antibacterial activities of the species Desmapsamma anchorata, Dysidea etheria, and Echinodictyum dendroides. The chemical profile involved identifying and quantifying polyphenols, and antioxidant activity was evaluated using various methods. The antibacterial and modulatory activities were evaluated using microdilution against pathogenic strains. The extracts contained a low amount of polyphenols. In the antioxidant assays, the EACDa and EMDa extracts exhibited better inhibitory results. In the antibacterial evaluation, extracts presented MIC ≥1024 μg mL. The modulation of the extracts combined with antibiotics showed significant effects against the multiresistant bacterium Pseudomonas aeruginosa. This study contributes to the deepening of chemical and biological knowledge of sponge species. It indicates that their extracts can act as good modulators of bacterial resistance to aminoglycoside antibiotics, which requires further investigation into their mechanisms of action.
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