AI Article Synopsis
- The popularity of nutraceuticals has surged in recent years, especially post-COVID-19, due to their accessibility, affordability, and general safety profile.
- While many nutraceuticals are safe, some carry risks of toxicity, and there is insufficient safety data for many due to a lack of comprehensive studies.
- The safety of nutraceuticals can be affected by contamination, and understanding pharmacokinetics and interaction studies is crucial for assessing their safety when used alongside other medications.
Article Abstract
During the past few decades and especially during and after the COVID-19 pandemic, the use of nutraceuticals has become increasingly popular in both humans and animals due to their easy access, cost-effectiveness, and tolerability with a wide margin of safety. While some nutraceuticals are safe, others have an inherent toxic potential. For a large number of nutraceuticals, no toxicity/safety data are available due to a lack of pharmacological/toxicological studies. The safety of some nutraceuticals can be compromised via contamination with toxic plants, metals, mycotoxins, pesticides, fertilizers, drugs of abuse, etc. Knowledge of pharmacokinetic/toxicokinetic studies and biomarkers of exposure, effect, and susceptibility appears to play a pivotal role in the safety and toxicity assessment of nutraceuticals. Interaction studies are essential to determine efficacy, safety, and toxicity when nutraceuticals and therapeutic drugs are used concomitantly or when polypharmacy is involved. This chapter describes various aspects of nutraceuticals, particularly their toxic potential, and the factors that influence their safety.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-1-0716-4003-6_10 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In vitro gas production and rumen fermentation for diets containing increasing levels of Panicum maximum cv. Mombasa with or without spirulina.
Trop Anim Health Prod
January 2025
Animal Production Department, Faculty of Agriculture, Ain-Shams University, 68 Hadayek Shoubra, Cairo, 111241, Egypt.
This study was designed to evaluate the effect of substituting alfalfa hay with graded levels panicum maximum without or with graded levels of spirulina supplementation on rumen fermentation and nutrient degradability. The evaluation was achieved through an in vitro study, rumen fluid was obtained from adult sheep aged 2 years (fed clover hay), immediately after slaughter. Experimental diets were formulated as isonitrogenous and isocaloric and contained 40% forage.
View Article and Find Full Text PDFDraft genome sequence of Kei apple, an underutilized African tree crop.
Sci Data
January 2025
International Livestock Research Institute, P.O. Box 30709, Nairobi, 00100, Kenya.
To address food and nutrition security in the face of burgeoning global populations and erratic climatic conditions there is a need to include nutrient dense, climatic resilient but neglected indigenous fruit trees in agrifood systems. Here we present the draft genome sequence of Kei Apple, Dovyalis afra, a neglected indigenous African fruit tree with untapped potential to contribute to nutrient security and improved livelihoods. Our long-read-based genome assembly comprises 440 Mbp sequence across 1190 contigs with a N50 and L50 of 13.
View Article and Find Full Text PDFCarbohydrate supplementation maintains physical performance during short-term energy deficit despite reductions in exogenous glucose oxidation.
Am J Physiol Endocrinol Metab
January 2025
Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA.
Exogenous glucose oxidation is reduced 55% during aerobic exercise after three days of complete starvation. Whether energy deficits more commonly experienced by athletes and military personnel similarly affect exogenous glucose oxidation and what impact this has on physical performance remains undetermined. This randomized, longitudinal parallel study aimed to assess the effects of varying magnitudes of energy deficit (DEF) on exogenous glucoseoxidation and physical performance compared to energy balance (BAL).
View Article and Find Full Text PDFLongitudinal changes in psychological, physiological, and nutritional measures and predictors of success in Special Forces training.
Physiol Behav
January 2025
Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA, USA. Electronic address:
The mentally and physically challenging 19-20 day, multi-stressor US Army Special Forces Assessment and Selection (SFAS) course selects soldiers for Army Special Forces (SF) training. If selected, candidates enroll for advanced training in the 2-year Special Forces Qualification Course (SFQC) to qualify for the SF. This longitudinal study examined physiological, psychological, and nutritional status of soldiers before (pre-SFAS) and after SFAS (post-SFAS), and post-SFQC, to identify predictors of graduation from SFQC.
View Article and Find Full Text PDFThe prebiotic landscape: history, health and physiological benefits, and regulatory challenges - an IPA perspective part 1.
Benef Microbes
January 2025
Beneficial MicrobesConsultancy, Johan Karschstraat 3, 6709 TN Wageningen, The Netherlands.
Prebiotics are becoming increasingly recognized by consumers, health care professionals and regulators as important contributors to health. Nonetheless, the development, progress, and adoption of prebiotics is hindered by loose terminology, various misconceptions about sources and types of compounds that may be classified as prebiotics, and the lack of consensus on a definition that satisfies regulators. Evolving knowledge of the microbiome and its effects on host health has generated opportunities for modulation of the microbiota that can support host health.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!