Objective: The study was designed to evaluate the performance validity module of Advanced Clinical Solutions (ACS) against external criterion measures and compare two alternative aggregation methods for its five components.
Method: The ACS was evaluated against psychometrically defined criterion groups in a sample of 93 outpatients with TBI. In addition to the default method, the component performance validity tests (PVTs) were either dichotomized along a single cutoff (VI-ACS) or recoded to capture various (EI-ACS).
Results: The standard ACS model correctly classified 75-83% of the sample. The alternative aggregation methods produced superior overall correct classification: 80-91% (VI-ACS) and 86-91% (EI-ACS). Mild TBI was associated with higher failure rates than moderate/severe TBI. Failing just one of the five ACS components resulted in a 3- to 8-fold increase in the likelihood of failing criterion PVTs.
Conclusions: Results support the use of the standard PVT module for ACS: it is an effective measure of performance validity that is robust to moderate-to-severe TBI. Post-publication research on individual ACS components and methodological advances in PVT research provide an opportunity to enhance the overall classification accuracy of the ACS model. Passing stringent multivariate PVT cutoffs does not indicate valid performance.
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http://dx.doi.org/10.1080/23279095.2024.2406313 | DOI Listing |
J Orthop Surg Res
January 2025
Department of Rheumatology and Immunology, Affiliated Hospital of Yangzhou University, Yangzhou University, No. 368 Hanjiang Middle Road, Yangzhou, Jiangsu, 225000, China.
Rheumatoid arthritis (RA), a chronic inflammatory joint disease causing permanent disability, involves exosomes, nanosized mammalian extracellular particles. Circular RNA (circRNA) serves as a biomarker in RA blood samples. This research screened differentially expressed circRNAs in RA patient plasma exosomes for novel diagnostic biomarkers.
View Article and Find Full Text PDFJ Cheminform
January 2025
School of Systems Biomedical Science, Soongsil University, 369 Sangdo-ro, Dongjak-gu, 06978, Seoul, Republic of Korea.
G protein-coupled receptors (GPCRs) play vital roles in various physiological processes, making them attractive drug discovery targets. Meanwhile, deep learning techniques have revolutionized drug discovery by facilitating efficient tools for expediting the identification and optimization of ligands. However, existing models for the GPCRs often focus on single-target or a small subset of GPCRs or employ binary classification, constraining their applicability for high throughput virtual screening.
View Article and Find Full Text PDFBMC Pharmacol Toxicol
January 2025
Yanzhou District People's Hospital, Jining, Shandong, China.
Background: Osteoporosis (OP), often termed the "silent epidemic," poses a substantial public health burden. Emerging insights into the molecular functions of FBXW4 have spurred interest in its potential roles across various diseases.
Methods: This study explored FBXW4 by integrating DEGs from GEO datasets GSE2208, GSE7158, GSE56815, and GSE35956 with immune-related gene compilations from the ImmPort repository.
Cardiovasc Diabetol
January 2025
Department of Cardiology, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, People's Republic of China.
Background: Hypertension (HTN) is a global public health concern and a major risk factor for cardiovascular disease (CVD) and mortality. Insulin resistance (IR) plays a crucial role in HTN-related metabolic dysfunction, but its assessment remains challenging. The triglyceride-glucose (TyG) index and its derivatives (TyG-BMI, TyG-WC, and TyG-WHtR) have emerged as reliable IR markers.
View Article and Find Full Text PDFScand J Trauma Resusc Emerg Med
January 2025
Department of Emergency Medicine, Lausanne University Hospital and University of Lausanne, 21 Rue du Bugnon, BH 09, 1011, Lausanne, Switzerland.
Background: The Abbreviated Injury Scale (AIS) and Injury Severity Score (ISS) grade the severity of injuries and are useful for trauma audit and benchmarking. However, AIS coding is complex and requires specifically trained staff. A simple yet reliable scoring system is needed.
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