AI Article Synopsis
- The study of gut microbiota, especially its bacterial components, is important for understanding health and disease, but the role of gut viruses is becoming increasingly recognized for their impact on gut health and the immune system.
- Environmental stressors significantly affect both the host's immune response and the composition of the gut virome, which can disrupt gut-brain communication and influence neurological functions.
- This literature review aims to investigate how stress and gut virome interactions, along with immune system changes, can lead to the development of various diseases.
Article Abstract
The role of gut microbiota in health and disease is being thoroughly examined in various contexts, with a specific focus on the bacterial fraction due to its significant abundance. However, despite their lower abundance, viruses within the gut microbiota are gaining recognition for their crucial role in shaping the structure and function of the intestinal microbiota, with significant effects on the host as a whole, particularly the immune system. Similarly, environmental factors such as stress are key in modulating the host immune system, which in turn influences the composition of the gut virome and neurological functions through the bidirectional communication of the gut-brain axis. In this context, alterations in the host immune system due to stress and/or dysbiosis of the gut virome are critical factors in the development of both infectious and noninfectious diseases. The molecular mechanisms and correlation patterns between microbial species are not yet fully understood. This literature review seeks to explore the interconnected relationship between stress and the gut virome, with a focus on how this interaction is influenced by the host's immune system. We also discuss how disturbances in this finely balanced system can lead to the onset and/or progression of diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11418023 | PMC |
| http://dx.doi.org/10.1002/mbo3.1434 | DOI Listing |
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