AI Article Synopsis

  • Optic Atrophy (OA) can lead to microcystic macular edema (MME) in the retinal inner nuclear layer, with a study investigating its prevalence in non-glaucomatous OA patients over five years.
  • Out of 643 eyes examined, 15% developed MME, with varying prevalence depending on the underlying cause of OA, except for toxic/nutritional factors.
  • MME was linked to thinning of the ganglion cell and nerve fiber layers, reduced visual acuity, and INL thickening, but its presence does not help in diagnosing OA conditions.

Article Abstract

Optic Atrophy (OA) can be associated with the development of microcystic macular edema (MME) in the perifoveal retinal inner nuclear layer (INL). We aimed here to retrospectively determine the prevalence of MME in patients with non-glaucomatous OA in our tertiary ophthalmology department between 2015 and 2020. We then examined how MME affected the thicknesses of the different retinal layers and the differences in demographic and clinical characteristics between those patients who developed MME and those who did not. A total of 643 eyes (429 patients) were included (mean age 45.9 ± 17.8 years, 52% female). MME developed in 95 (15%) eyes and across all etiologies of OA except for toxic/nutritional causes, but the prevalence of MME varied between the different etiologies. The development of MME was associated with thinning of the ganglion cell layer (11.0 vs. 9.6 μm; = 0.001) and the retinal nerve fiber layer (10.1 vs. 9.15 μm; = 0.024), with INL thickening in the 3- and 6-mm diameter areas of the central fovea. Patients developing MME had significantly worse distance best-corrected visual acuity than those not developing MME (0.62 vs. 0.38 logMAR; = 0.002). Overall, the presence of MME in OA cannot be used to guide the diagnostic work-up of OA.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11417757PMC
http://dx.doi.org/10.3390/vision8030052DOI Listing

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