Tissue plasminogen activator associated pulmonary hemorrhage in patient with -associated arteriopathy.

Pulmonary hemorrhage after administration of tissue plasminogen activator (tPA) is a rare complication. We present a 15-year-old boy with a heterozygous pathogenic variant in who presented with right brachial artery aneurysm thrombosis treated initially with tPA, resulting in pulmonary hemorrhage. We hypothesize that the underlying pulmonary abnormalities caused by the pathogenic variant may be a risk factor for pulmonary hemorrhage after tPA administration.