Recent studies have shown that ultrashort plasma cell-free DNA (uscfDNA), a novel type of cfDNA fragment approximately 50 nucleotides long, differs from conventional monocyte-derived cfDNA in several aspects, including specific extraction requirements and a higher incidence of tumor-specific genetic alterations. uscfDNA shows promise in enhancing liquid biopsy sensitivity for cancer detection, with distinct methylation profiles observed in cancer patients. These findings suggest uscfDNA analysis could significantly improve non-invasive cancer diagnostics, offering new avenues for early detection and personalized medicine strategies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411157 | PMC |
| http://dx.doi.org/10.62347/UQTM2281 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
"On-off" elution mechanism facilitates the rapid LC/MS/MS-based analysis of peptide antibiotics in human plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
December 2024
Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs, Department of Pharmacy, The Third Hospital of Changsha, Changsha 410015, People's Republic of China. Electronic address:
Individualized medication with peptide antibiotics, guided by therapeutic drug monitoring, is essential to treat infections caused by multidrug-resistant bacteria. Peptide antibiotics exhibit an "on-off" elution mechanism on a C18 column, leading to adsorption at the column inlet in all-aqueous conditions. Unlike small molecules, column length minimally influences their retention, with longer columns simply broadening peptide antibiotic peaks due to unnecessary post-column volume.
View Article and Find Full Text PDFComparison of the effects of laser systems and cold atmospheric plasma on the surface roughness and shear bond strength of flexible hybrid ceramics.
Lasers Med Sci
November 2024
Faculty of Dentistry, Department of Prosthodontics, Karadeniz Technical University, Trabzon, Turkey.
Article Synopsis
- The study compared the effects of different surface treatments on flexible hybrid ceramics, specifically using laser systems and cold atmospheric plasma (CAP) on surface roughness (Ra) and shear bond strength (SBS).
- Eighty samples were divided into five treatment groups and exposed to various methods including hydrofluoric acid and different lasers, which were calibrated to specific settings to ensure precise application.
- Results showed that the ultrafast fiber laser treatment resulted in the highest Ra values, while the best SBS was achieved with samples treated with hydrofluoric acid followed by the ultrafast fiber laser, suggesting that this method enhances bonding strength without risking thermal damage.
Ultra-Short Pulses Laser Heating of Dielectrics: A Semi-Classical Analytical Model.
Materials (Basel)
November 2024
National Institute for Laser, Plasma and Radiation Physics (INFLPR), Magurele, 077125 Ilfov, Romania.
Femtosecond laser pulses are currently regarded as an emerging and promising tool for processing wide bandgap dielectric materials across a variety of high-end applications, although the associated physical phenomena are not yet fully understood. To address these challenges, we propose an original, fully analytical model combined with Two Temperatures Model (TTM) formalism. The model is applied to describe the interaction of fs laser pulses with a typical dielectric target (e.
View Article and Find Full Text PDFThe Construction and Mechanism Study of High-Speed Carrier Transport Channel in Gallium Arsenide Homojunction Toward High-Performance Photoelectrochemical Photodetector.
Small
December 2024
Guangdong Engineering Technology Research Center of Efficient Green Energy and Environment Protection Materials, School of Electronics and Information Engineering, South China Normal University, Foshan, 528225, P. R. China.
The energy band structure and surface/interface properties are prerequisite for not only preserving the intrinsic material quality but also manipulating carrier transport behavior for photoelectrochemical (PEC) photodetection. How to precisely design/regulate the band structure and surface/interface properties of semiconductor materials is the key to improving the performance of PEC photodetection. Herein, the quintuple heterotypic homojunction (QH) GaAs film is fabricated with a gradient energy band via plasma-assisted molecular beam epitaxy for constructing a high-speed carrier transport channel in PEC photodetection, which can efficiently drive the separation and transport of photogenerated electron-hole pairs.
View Article and Find Full Text PDFUltrashort plasma cell-free DNA: a novel non-invasive marker for cancer diagnostics.
Am J Clin Exp Immunol
August 2024
Department of Spleen and Stomach Diseases, Kunshan Hospital of Traditional Chinese Medicine Kunshan 215300, Jiangsu, China.
Recent studies have shown that ultrashort plasma cell-free DNA (uscfDNA), a novel type of cfDNA fragment approximately 50 nucleotides long, differs from conventional monocyte-derived cfDNA in several aspects, including specific extraction requirements and a higher incidence of tumor-specific genetic alterations. uscfDNA shows promise in enhancing liquid biopsy sensitivity for cancer detection, with distinct methylation profiles observed in cancer patients. These findings suggest uscfDNA analysis could significantly improve non-invasive cancer diagnostics, offering new avenues for early detection and personalized medicine strategies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!