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Identification of pyrimidine metabolism-based molecular subtypes and prognostic signature to predict immune landscape and guide clinical treatment in prostate cancer.
Ann Med
December 2025
Department of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Background: We previously described the enrichment of plasma exosome metabolites in CRPC, PCa, and TFC cohorts, and found significant differences in pyrimidine metabolites. The PMGs is associated with the clinical prognosis of several cancers, but its biological role in PCa is still unclear.
Methods: This study extracted 98 reliable PMGs, and analyzed their somatic mutations, expression levels, and prognostic significance.
From Diagnosis to Emergency: Mediastinal Abscess After Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in a Patient With Sarcoidosis.
Cureus
December 2024
Internal Medicine, Unidade Local de Saúde do Oeste - Hospital Distrital de Caldas da Rainha, Caldas da Rainha, PRT.
Sarcoidosis is a systemic granulomatous disease of unknown etiology, primarily affecting the lungs and the lymphatic system. Its diagnosis is challenging, and in many cases, it requires histopathological confirmation through the identification of non-caseating granulomas. The presented case illustrates its diagnostic complexity and highlights a rare, delayed complication associated with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA).
View Article and Find Full Text PDFFactors Associated with Management of Workplace Violence Competence Among Chinese Nursing Interns.
Risk Manag Healthc Policy
January 2025
School of Nursing, Xiangnan University, Chenzhou, 423000, People's Republic of China.
Purpose: The cases of workplace violence (WPV) experienced by nurses and nursing students in recent years has become alarming high. However, managing and developing WPV competence among nursing students remain underreported. Therefore, this study investigated the current status of management of workplace violence competence (MWVC) and identify associated factors affecting their MWVC among nursing interns.
View Article and Find Full Text PDFMultimodality Imaging in the Diagnostic Work-Up of Patients With Cardiac Masses: State-of-the-Art Review.
JACC CardioOncol
December 2024
Cardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, Bologna, Italy.
Cardiac masses encompass a diverse range of benign and malignant tumors as well as pseudotumors. Accurate histologic identification is essential for guiding appropriate treatment, yet the diagnostic process remains challenging. Although biopsy is traditionally the diagnostic gold standard, its invasive nature and associated risks limit its application.
View Article and Find Full Text PDFThe potential of digital health interventions to address health system challenges in Southeast Asia: A scoping review.
Digit Health
January 2025
The George Institute for Global Health, UNSW, New Delhi, India.
Objective: The World Health Organization (WHO) Southeast Asian region, comprising a quarter of the global population, faces significant healthcare challenges influenced by diverse economic and social conditions. The objective of this study is to map the Digital Health Intervention (DHI) functionalities across the nine axes of the healthcare system challenges (HSCs) model; we use WHO's DHIs classification framework and the Health System Challenges model. Our study findings help identify the gaps in the potential of the existing DHIs in addressing health system challenges in low- and middle-income countries.
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