AI Article Synopsis
- A DNA nanogel that can cleave itself has been created, and it's loaded with a specific type of RNA molecule called a splice-switch oligonucleotide (SSO).
- This nanogel is designed to break apart under acidic conditions, specifically at a pH of 5.0.
- When the nanogel disintegrates, it releases the SSO in its original form without any changes.
Article Abstract
A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.
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| http://dx.doi.org/10.1039/d4cc01942c | DOI Listing |
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