Over the last few years, during the pandemic, the Brazilian population has suffered several problems, ranging from health to socioeconomic impacts. When we consider Brazilian science, there has been an undeniable scientific delay generated by the pandemic, especially in areas that are not related to the coronavirus. In this context, with the aim of fostering collaboration among researchers in the field of Developmental Origins of Health and Diseases (DOHaD) and enhancing the potential for implementing public health strategies to prevent noncommunicable chronic diseases, the Brazilian Association of Developmental Origins of Health and Diseases (DOHaD Brazil) was established in 2020. In this narrative, we explore the effects of the COVID-19 pandemic in Brazil, focusing on its impacts on scientific research conducted in universities. Additionally, we underscore the significance of the DOHaD Brazil Association, particularly from the perspective of young researchers engaged in DOHaD research in Brazil.
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Maternal swimming with overload allied to postnatal high-fat, high-sugar diet induce subtle impairment on rat offspring's ovarian redox homeostasis.
Reprod Fertil Dev
December 2024
Programa de Pós-graduação em Ciências Biológicas: Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; and Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Context The Developmental Origins of Health and Disease (DOHaD) concept suggests that early-life interventions significantly influence the long-term health outcomes of offspring. Emerging evidence supports that maternal physical exercise and balanced nutrition can positively impact the health of the next generation. Aims This study investigated the effects of maternal swimming combined with postnatal high-fat, high-sugar (HFHS) diet on the ovarian health of adult female Wistar rat offspring.
View Article and Find Full Text PDFInfluence of aging and maternal protein restriction on PIWI-interacting RNA expression in the offspring rat ventral prostate.
Sci Rep
December 2024
Department of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil.
Article Synopsis
- The Developmental Origins of Health and Disease (DOHaD) concept links early adverse conditions, like maternal protein restriction, to chronic diseases, specifically prostate cancer (PCa).
- The study investigated the expression of piwi-interacting RNAs (piRNAs) in the ventral prostate of rat offspring affected by maternal malnutrition, revealing developmental delays and altered tissue structures.
- Findings suggest that maternal malnutrition influences piRNA expression, which may have long-term effects on prostate health and increase the risk of disorders as the offspring age.
High-fat diet during lactation, as opposed to during adolescence or gestation, programs cardiometabolic and autonomic dysfunctions in adult offspring.
Brain Res
November 2024
Laboratory of Experimental DOHaD, Department of Biotechnology, Genetics, and Cell Biology, State University of Maringá, Maringá 87090-020, Brazil.
The Developmental Origins of Health and Disease (DOHaD) concept has been established for three decades. Many studies have shown that, besides pregnancy, other plastic phases (mainly preconception, lactation, and infancy-adolescence) are also sensitive to environmental changes, including nutritional conditions, that can program health or disease later in life. This study compared the susceptibility of the gestation, lactation and adolescence to a high-fat diet (HFD) intervention to program rats into autonomic nervous system imbalance and cardiometabolic dysfunction in adulthood.
View Article and Find Full Text PDFGut dysbiosis mediates the association between antibiotic exposure and chronic disease.
Front Med (Lausanne)
November 2024
Servicio de Gastroenterología, Hospital Médica Sur, Ciudad de México, Mexico.
Article Synopsis
- Antibiotics are essential for treating infections and preventing illness, but their use, especially in infants, can lead to long-term health issues due to changes in gut microbiota.
- The disruption of gut microbiota, known as gut dysbiosis, is linked to various chronic diseases like obesity, diabetes, autoimmune disorders, and some cancers.
- Probiotics may help counteract the negative effects of gut dysbiosis in patients with chronic diseases, potentially improving their health and inflammation markers.
Early exposure to a cholinergic receptor blocking agent mitigates adult obesity and protects pancreatic islet function in male rats.
Am J Physiol Endocrinol Metab
January 2025
Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringa, Maringa, Brazil.
We tested the hypothesis that attenuation of the circulating insulin level in rats during early life can provide sustained protection against diet-induced obesity and metabolic dysfunction in adulthood. Male Wistar rats received intraperitoneal scopolamine butylbromide (SB) during the first 12 days of suckling, whereas control rats received 0.9% saline injections.
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