To understand molecular characteristics and antibiotic resistance of () isolated from children in China, and provide data support the development of disease risk assessment and burden studies. A total of 155 strains of isolated from children aged <12 years in 14 provinces (autonomous regions, municipalities) in China from 2010 to 2023 were used for the analyses on molecular characteristics and antibiotic resistance of by PCR and drug susceptibility test. A total of 26 sequence types (STs) and 18 ribotypes (RTs) were identified in the 155 isolates, in which ST3 (20.65%), ST54 (16.13%), ST35 (12.90%), and RT012/ICDC007 (14.84%), RT001/ICDC001 (11.61%), RT046/ICDC018 (8.39%) were the most common. One highly virulent strain with RT078 and 27 non-toxin-producing strains were also found; the predominant toxin gene was ++-. All the strains were sensitive to metronidazole and vancomycin, and there were 29 multidrug-resistant strains, in which 1 strain was resistant to all the seven antibiotics except for vancomycin and metronidazole. Molecular characteristics and antibiotic resistance of in children were similar to those in whole population in China, but there were regional distribution differences. It is necessary to strengthen the routine drug-resistance surveillance for infection in children in China.
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| http://dx.doi.org/10.3760/cma.j.cn112338-20240530-00315 | DOI Listing |
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