Gibberellic Acid (GA): A Versatile Chiral Building Block for Syntheses of Pharmaceutical Agents.

Chem Biodivers

Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös utca 6, H-6720, Szeged, Hungary.

Published: September 2024

Gibberellic acid (GA), an ent-kaurene tetracyclic diterpene, has been considered to be a chiral pool for the chemical transformation of significant heterocyclic compounds. This chiral pool continues to influence modern synthetic chemistry as an inexpensive and versatile starting material since it is widely applied in agriculture. This review focuses on the stereoselective syntheses of bioactive agents with pharmaceutical potency prepared from Gibberellic acid.

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http://dx.doi.org/10.1002/cbdv.202401823DOI Listing

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